DegronMD

Uniprot ID: Q92913

Source protein: Fibroblast growth factor 13

Source gene: FGF13

Class: LIG_APCC_ABBA_1

Location: 201:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5791

ASA_SCORE: 94.0333

COIL: 0.6963

CONS_SCORE: 0.5674

DSS_SCORE: 0.3944

HELIX: 0.2678

FCONS_SCORE: 0.9436

RIG_SCORE: 0.7586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K215M	TCGA-55-8203	LUAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.0833
p.M213L	TCGA-91-6836	LUAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.1389
p.A202S	TCGA-95-7039	LUAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.6477
p.A202S	TCGA-A5-A0G1	UCEC	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.6477
p.A202S	TCGA-A6-5665	COAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.6477
p.G192C	TCGA-AP-A0LM	UCEC	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.0833
p.A201V	TCGA-B7-5816	STAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.6936
p.F204V	TCGA-D1-A16X	UCEC	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.7068
p.K196T	TCGA-D7-A4Z0	STAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.1944
p.P208L	TCGA-EE-A2GD	SKCM	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.7222
p.P208S	TCGA-EE-A2GD	SKCM	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.7222
p.N198D	TCGA-EI-6884	READ	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.25
p.K207T	TCGA-VQ-A8E7	STAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.3056
p.K197T	TCGA-VQ-A8PK	STAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	0.3333
p.A192S	DO9756	COAD	ICGC	VAMYKE	LIG_APCC_ABBA_1	0.0833
p.A192S	DO23907	LUAD	ICGC	VAMYKE	LIG_APCC_ABBA_1	0.0833
p.A192S	DO42472	UCEC	ICGC	VAMYKE	LIG_APCC_ABBA_1	0.0833
p.T213M	DO52478	COCA	ICGC	VAMYKE	LIG_APCC_ABBA_1	0.1389
p.A202T	DO231138	LAML	ICGC	VAMYKE	LIG_APCC_ABBA_1	0.6028
p.K205M	DO218928	LUAD	ICGC	VAMYKE	LIG_APCC_ABBA_1	0.6951
p.D211N	ACH-000766	Lung Cancer	CCLE	VAMYKE	LIG_APCC_ABBA_1	0.1944
p.D211N	NCI-H1648	lung	COSMIC	VAMYKE	LIG_APCC_ABBA_1	0.1944
p.G216V	OV-7	ovary	COSMIC	VAMYKE	LIG_APCC_ABBA_1	0.0556
p.D192N	NCI-H1648	lung	COSMIC	VAMYKE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92913	Fibroblast growth factor 13	LIG_APCC_ABBA_1	201:206	VAMYKE	APC,CDC20,FZR1	0.5791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons