DegronMD

Uniprot ID: Q9H2S9

Source protein: Zinc finger protein Eos

Source gene: IKZF4

Class: LIG_APCC_ABBAyCdc20_2

Location: 100:106

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.963

ASA_SCORE: 80.3857

COIL: 0.4241

CONS_SCORE: 0.6384

DSS_SCORE: 0.4924

HELIX: 0.036

FCONS_SCORE: 1.1053

RIG_SCORE: 0.7165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L94R	TCGA-AP-A0LM	UCEC	TCGA	KVEMYSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G98A	DO229016	COCA	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P104S	DO233889	GACA	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	0.6752
p.P104T	DO14398	HNSC	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	0.7031
p.C94F	DO229025	LICA	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R108W	DO51407	PRAD	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R108Q	DO38400	STAD	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R108Q	DO41871	UCEC	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G106S	DO47911	STAD	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	0.6993
p.G105E	ACH-000899	Skin Cancer	CCLE	KVEMYSD	LIG_APCC_ABBAyCdc20_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2S9	Zinc finger protein Eos	LIG_APCC_ABBAyCdc20_2	100:106	KVEMYSD	APC,CDC20,FZR1	0.963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons