DegronMD

Uniprot ID: O75339

Source protein: Cartilage intermediate layer protein 1

Source gene: CILP

Class: LIG_APCC_ABBAyCdc20_2

Location: 677:683

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7257

ASA_SCORE: 62.8286

COIL: 0.3366

CONS_SCORE: 0.69

DSS_SCORE: 0.3967

HELIX: 0.0149

FCONS_SCORE: 1.1198

RIG_SCORE: 0.8031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T669I	TCGA-AJ-A3OL	UCEC	TCGA	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T669I	DO43001	UCEC	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.K688N	TCGA-EO-A3B0	UCEC	TCGA	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.K688N	DO219773	UCEC	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q686H	TCGA-F4-6461	COAD	TCGA	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q686H	DO10662	COAD	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q686H	ACH-001610	Brain Cancer	CCLE	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q686K	TCGA-FR-A8YC	SKCM	TCGA	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q686K	DO50301	SKCM	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.S684L	TCGA-G4-6588	COAD	TCGA	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S684L	DO10140	COAD	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S684L	DO222662	MELA	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.V678M	SIDM00557	Neuroblastoma	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V678M	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V678M	SIDM00640	Mesothelioma	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V678M	SIDM01756	Chronic Myelogenous Leukemia	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V678M	SIDM01763	Rhabdomyosarcoma	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.6097
p.T669P	SIDM00129	Melanoma	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T669P	ACH-002121	Skin Cancer	CCLE	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T669P	G-MEL	skin	COSMIC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75339	Cartilage intermediate layer protein 1	LIG_APCC_ABBAyCdc20_2	677:683	KVKVHLD	APC,CDC20,FZR1	0.7257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons