DegronMD - O75339(CILP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1127R	TCGA-24-1927	OV	TCGA	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.1667
p.Q1127R	DO31604	OV	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.1667
p.S1140Y	TCGA-49-AAR3	LUAD	TCGA	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.8231
p.S1140Y	DO218919	LUAD	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.8231
p.T669I	TCGA-AJ-A3OL	UCEC	TCGA	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.0833
p.T669I	TCGA-AJ-A3OL	UCEC	TCGA	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.1111
p.T669I	DO43001	UCEC	ICGC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.0833
p.T669I	DO43001	UCEC	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.1111
p.P1137L	TCGA-EE-A29T	SKCM	TCGA	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.7582
p.P1137L	DO37742	SKCM	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.7582
p.P1137S	TCGA-EE-A29T	SKCM	TCGA	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.6752
p.P1137S	DO37742	SKCM	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.6752
p.K688N	TCGA-EO-A3B0	UCEC	TCGA	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation substituting flanking lysine	0.3056
p.K688N	TCGA-EO-A3B0	UCEC	TCGA	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation substituting flanking lysine	0.3056
p.K688N	DO219773	UCEC	ICGC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation substituting flanking lysine	0.3056
p.K688N	DO219773	UCEC	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation substituting flanking lysine	0.3056
p.Q686H	TCGA-F4-6461	COAD	TCGA	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.25
p.Q686H	TCGA-F4-6461	COAD	TCGA	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.25
p.Q686H	DO10662	COAD	ICGC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.25
p.Q686H	DO10662	COAD	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.25
p.Q686H	ACH-001610	Brain Cancer	CCLE	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.25
p.Q686H	ACH-001610	Brain Cancer	CCLE	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.25
p.P1141S	TCGA-FR-A726	SKCM	TCGA	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.3056
p.P1141S	DO48665	SKCM	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.3056
p.Q686K	TCGA-FR-A8YC	SKCM	TCGA	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.25
p.Q686K	TCGA-FR-A8YC	SKCM	TCGA	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.25
p.Q686K	DO50301	SKCM	ICGC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.25
p.Q686K	DO50301	SKCM	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.25
p.S684L	TCGA-G4-6588	COAD	TCGA	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.3056
p.S684L	TCGA-G4-6588	COAD	TCGA	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.3056
p.S684L	DO10140	COAD	ICGC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.3056
p.S684L	DO10140	COAD	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.3056
p.S684L	DO222662	MELA	ICGC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.3056
p.S684L	DO222662	MELA	ICGC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.3056
p.R1126H	DO234199	ESAD	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.1389
p.R1126H	ACH-000980	Lung Cancer	CCLE	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.1389
p.R1126C	DO233205	GACA	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.1389
p.V678M	SIDM00557	Neuroblastoma	GDSC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation altering degron motif	0.6097
p.V678M	SIDM00557	Neuroblastoma	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation altering degron motif	0.6097
p.V678M	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation altering degron motif	0.6097
p.V678M	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation altering degron motif	0.6097
p.V678M	SIDM00640	Mesothelioma	GDSC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation altering degron motif	0.6097
p.V678M	SIDM00640	Mesothelioma	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation altering degron motif	0.6097
p.V678M	SIDM01756	Chronic Myelogenous Leukemia	GDSC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation altering degron motif	0.6097
p.V678M	SIDM01756	Chronic Myelogenous Leukemia	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation altering degron motif	0.6097
p.V678M	SIDM01763	Rhabdomyosarcoma	GDSC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation altering degron motif	0.6097
p.V678M	SIDM01763	Rhabdomyosarcoma	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation altering degron motif	0.6097
p.T669P	SIDM00129	Melanoma	GDSC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.0833
p.T669P	SIDM00129	Melanoma	GDSC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.1111
p.T669P	ACH-002121	Skin Cancer	CCLE	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.0833
p.T669P	ACH-002121	Skin Cancer	CCLE	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.1111
p.T669P	G-MEL	skin	COSMIC	VKVHLD	LIG_APCC_ABBA_1	678:683	Mutation rewiring degron network	0.0833
p.T669P	G-MEL	skin	COSMIC	KVKVHLD	LIG_APCC_ABBAyCdc20_2	677:683	Mutation rewiring degron network	0.1111
p.G1148R	SIDM01561	Melanoma	GDSC	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.1111
p.G1148R	ACH-000799	Skin Cancer	CCLE	LQSTPAQS	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CILP

UniProt ID: O75339

Entrez ID: 8483

Protein name: Cartilage intermediate layer protein 1 (CILP-1) (Cartilage intermediate-layer protein) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CILP in