DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VKVHLD
Uniprot ID:
O75339
Source protein:
Cartilage intermediate layer protein 1
Source gene:
CILP
Class:
LIG_APCC_ABBA_1
Location:
678:683
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8696
ASA_SCORE:
49.7333
COIL:
0.2608
CONS_SCORE:
0.702
DSS_SCORE:
0.3971
HELIX:
0.0082
FCONS_SCORE:
1.1545
RIG_SCORE:
0.8127
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T669I
TCGA-AJ-A3OL
UCEC
TCGA
VKVHLD
LIG_APCC_ABBA_1
0.0833
p.T669I
DO43001
UCEC
ICGC
VKVHLD
LIG_APCC_ABBA_1
0.0833
p.K688N
TCGA-EO-A3B0
UCEC
TCGA
VKVHLD
LIG_APCC_ABBA_1
0.3056
p.K688N
DO219773
UCEC
ICGC
VKVHLD
LIG_APCC_ABBA_1
0.3056
p.Q686H
TCGA-F4-6461
COAD
TCGA
VKVHLD
LIG_APCC_ABBA_1
0.25
p.Q686H
DO10662
COAD
ICGC
VKVHLD
LIG_APCC_ABBA_1
0.25
p.Q686H
ACH-001610
Brain Cancer
CCLE
VKVHLD
LIG_APCC_ABBA_1
0.25
p.Q686K
TCGA-FR-A8YC
SKCM
TCGA
VKVHLD
LIG_APCC_ABBA_1
0.25
p.Q686K
DO50301
SKCM
ICGC
VKVHLD
LIG_APCC_ABBA_1
0.25
p.S684L
TCGA-G4-6588
COAD
TCGA
VKVHLD
LIG_APCC_ABBA_1
0.3056
p.S684L
DO10140
COAD
ICGC
VKVHLD
LIG_APCC_ABBA_1
0.3056
p.S684L
DO222662
MELA
ICGC
VKVHLD
LIG_APCC_ABBA_1
0.3056
p.V678M
SIDM00557
Neuroblastoma
GDSC
VKVHLD
LIG_APCC_ABBA_1
0.6097
p.V678M
SIDM00939
Non-Small Cell Lung Carcinoma
GDSC
VKVHLD
LIG_APCC_ABBA_1
0.6097
p.V678M
SIDM00640
Mesothelioma
GDSC
VKVHLD
LIG_APCC_ABBA_1
0.6097
p.V678M
SIDM01756
Chronic Myelogenous Leukemia
GDSC
VKVHLD
LIG_APCC_ABBA_1
0.6097
p.V678M
SIDM01763
Rhabdomyosarcoma
GDSC
VKVHLD
LIG_APCC_ABBA_1
0.6097
p.T669P
SIDM00129
Melanoma
GDSC
VKVHLD
LIG_APCC_ABBA_1
0.0833
p.T669P
ACH-002121
Skin Cancer
CCLE
VKVHLD
LIG_APCC_ABBA_1
0.0833
p.T669P
G-MEL
skin
COSMIC
VKVHLD
LIG_APCC_ABBA_1
0.0833
Drug responses associated with CILP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKVHLD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75339
Cartilage intermediate layer protein 1
LIG_APCC_ABBA_1
678:683
VKVHLD
APC,CDC20,FZR1
0.8696
More...