DegronMD

Uniprot ID: O75339

Source protein: Cartilage intermediate layer protein 1

Source gene: CILP

Class: LIG_APCC_ABBA_1

Location: 678:683

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8696

ASA_SCORE: 49.7333

COIL: 0.2608

CONS_SCORE: 0.702

DSS_SCORE: 0.3971

HELIX: 0.0082

FCONS_SCORE: 1.1545

RIG_SCORE: 0.8127

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V678M	SIDM00557	Neuroblastoma	GDSC	VKVHLD	LIG_APCC_ABBA_1	0.6097
p.V678M	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	VKVHLD	LIG_APCC_ABBA_1	0.6097
p.V678M	SIDM00640	Mesothelioma	GDSC	VKVHLD	LIG_APCC_ABBA_1	0.6097
p.V678M	SIDM01756	Chronic Myelogenous Leukemia	GDSC	VKVHLD	LIG_APCC_ABBA_1	0.6097
p.V678M	SIDM01763	Rhabdomyosarcoma	GDSC	VKVHLD	LIG_APCC_ABBA_1	0.6097
p.K688N	TCGA-EO-A3B0	UCEC	TCGA	VKVHLD	LIG_APCC_ABBA_1	0.3056
p.K688N	DO219773	UCEC	ICGC	VKVHLD	LIG_APCC_ABBA_1	0.3056
p.S684L	TCGA-G4-6588	COAD	TCGA	VKVHLD	LIG_APCC_ABBA_1	0.3056
p.S684L	DO10140	COAD	ICGC	VKVHLD	LIG_APCC_ABBA_1	0.3056
p.S684L	DO222662	MELA	ICGC	VKVHLD	LIG_APCC_ABBA_1	0.3056
p.Q686H	TCGA-F4-6461	COAD	TCGA	VKVHLD	LIG_APCC_ABBA_1	0.25
p.Q686H	DO10662	COAD	ICGC	VKVHLD	LIG_APCC_ABBA_1	0.25
p.Q686H	ACH-001610	Brain Cancer	CCLE	VKVHLD	LIG_APCC_ABBA_1	0.25
p.Q686K	TCGA-FR-A8YC	SKCM	TCGA	VKVHLD	LIG_APCC_ABBA_1	0.25
p.Q686K	DO50301	SKCM	ICGC	VKVHLD	LIG_APCC_ABBA_1	0.25
p.T669I	TCGA-AJ-A3OL	UCEC	TCGA	VKVHLD	LIG_APCC_ABBA_1	0.0833
p.T669I	DO43001	UCEC	ICGC	VKVHLD	LIG_APCC_ABBA_1	0.0833
p.T669P	SIDM00129	Melanoma	GDSC	VKVHLD	LIG_APCC_ABBA_1	0.0833
p.T669P	ACH-002121	Skin Cancer	CCLE	VKVHLD	LIG_APCC_ABBA_1	0.0833
p.T669P	G-MEL	skin	COSMIC	VKVHLD	LIG_APCC_ABBA_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75339	Cartilage intermediate layer protein 1	LIG_APCC_ABBA_1	678:683	VKVHLD	APC,CDC20,FZR1	0.8696	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons