DegronMD

Uniprot ID: O75339

Source protein: Cartilage intermediate layer protein 1

Source gene: CILP

Class: DEG_SCF_FBW7_1

Location: 1133:1140

E3 ligase: FBXW7

DEGRON score: 0.9739

ASA_SCORE: 63.0625

COIL: 0.7198

CONS_SCORE: 0.3796

DSS_SCORE: 0.4845

HELIX: 0.1494

FCONS_SCORE: 1.0364

RIG_SCORE: 0.6984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1127R	TCGA-24-1927	OV	TCGA	LQSTPAQS	DEG_SCF_FBW7_1	0.1667
p.Q1127R	DO31604	OV	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	0.1667
p.S1140Y	TCGA-49-AAR3	LUAD	TCGA	LQSTPAQS	DEG_SCF_FBW7_1	0.8231
p.S1140Y	DO218919	LUAD	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	0.8231
p.P1137L	TCGA-EE-A29T	SKCM	TCGA	LQSTPAQS	DEG_SCF_FBW7_1	0.7582
p.P1137L	DO37742	SKCM	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	0.7582
p.P1137S	TCGA-EE-A29T	SKCM	TCGA	LQSTPAQS	DEG_SCF_FBW7_1	0.6752
p.P1137S	DO37742	SKCM	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	0.6752
p.P1141S	TCGA-FR-A726	SKCM	TCGA	LQSTPAQS	DEG_SCF_FBW7_1	0.3056
p.P1141S	DO48665	SKCM	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	0.3056
p.R1126H	DO234199	ESAD	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	0.1389
p.R1126H	ACH-000980	Lung Cancer	CCLE	LQSTPAQS	DEG_SCF_FBW7_1	0.1389
p.R1126C	DO233205	GACA	ICGC	LQSTPAQS	DEG_SCF_FBW7_1	0.1389
p.G1148R	SIDM01561	Melanoma	GDSC	LQSTPAQS	DEG_SCF_FBW7_1	0.1111
p.G1148R	ACH-000799	Skin Cancer	CCLE	LQSTPAQS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75339	Cartilage intermediate layer protein 1	DEG_SCF_FBW7_1	1133:1140	LQSTPAQS	FBXW7	0.9739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons