DegronMD

Uniprot ID: Q9C073

Source protein: Protein FAM117A

Source gene: FAM117A

Class: LIG_APCC_ABBAyCdc20_2

Location: 346:352

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9822

ASA_SCORE: 83.2429

COIL: 0.4619

CONS_SCORE: 0.6569

DSS_SCORE: 0.4985

HELIX: 0.4251

FCONS_SCORE: 1.0147

RIG_SCORE: 0.7917

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L360V	TCGA-5S-A9Q8	UCEC	TCGA	KVRVFEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L360V	DO50074	UCEC	ICGC	KVRVFEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E345D	TCGA-EO-A22X	UCEC	TCGA	KVRVFEE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E345D	DO43907	UCEC	ICGC	KVRVFEE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P341S	TCGA-GN-A26A	SKCM	TCGA	KVRVFEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P341S	DO37861	SKCM	ICGC	KVRVFEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.T354M	DO48388	BLCA	ICGC	KVRVFEE	LIG_APCC_ABBAyCdc20_2	0.7222
p.S355Y	DO232224	PBCA	ICGC	KVRVFEE	LIG_APCC_ABBAyCdc20_2	0.6944
p.D359E	ACH-001513	Cervical Cancer	CCLE	KVRVFEE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C073	Protein FAM117A	LIG_APCC_ABBAyCdc20_2	346:352	KVRVFEE	APC,CDC20,FZR1	0.9822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons