DegronMD - Q9C073(FAM117A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L360V	TCGA-5S-A9Q8	UCEC	TCGA	VRVFEE	LIG_APCC_ABBA_1	347:352	Mutation rewiring degron network	0.1111
p.L360V	TCGA-5S-A9Q8	UCEC	TCGA	KVRVFEE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1111
p.L360V	DO50074	UCEC	ICGC	VRVFEE	LIG_APCC_ABBA_1	347:352	Mutation rewiring degron network	0.1111
p.L360V	DO50074	UCEC	ICGC	KVRVFEE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1111
p.E345D	TCGA-EO-A22X	UCEC	TCGA	VRVFEE	LIG_APCC_ABBA_1	347:352	Mutation rewiring degron network	0.2778
p.E345D	TCGA-EO-A22X	UCEC	TCGA	KVRVFEE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.3056
p.E345D	DO43907	UCEC	ICGC	VRVFEE	LIG_APCC_ABBA_1	347:352	Mutation rewiring degron network	0.2778
p.E345D	DO43907	UCEC	ICGC	KVRVFEE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.3056
p.P341S	TCGA-GN-A26A	SKCM	TCGA	VRVFEE	LIG_APCC_ABBA_1	347:352	Mutation rewiring degron network	0.1667
p.P341S	TCGA-GN-A26A	SKCM	TCGA	KVRVFEE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1944
p.P341S	DO37861	SKCM	ICGC	VRVFEE	LIG_APCC_ABBA_1	347:352	Mutation rewiring degron network	0.1667
p.P341S	DO37861	SKCM	ICGC	KVRVFEE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1944
p.T354M	DO48388	BLCA	ICGC	VRVFEE	LIG_APCC_ABBA_1	347:352	Mutation blocking phosphorylation signal	0.7222
p.T354M	DO48388	BLCA	ICGC	KVRVFEE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation blocking phosphorylation signal	0.7222
p.P37S	DO23204	LINC	ICGC	PRAGLQPLR	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.5641
p.S355Y	DO232224	PBCA	ICGC	VRVFEE	LIG_APCC_ABBA_1	347:352	Mutation blocking phosphorylation signal	0.6944
p.S355Y	DO232224	PBCA	ICGC	KVRVFEE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation blocking phosphorylation signal	0.6944
p.A34T	ACH-000843	Lung Cancer	CCLE	PRAGLQPLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.25
p.D359E	ACH-001513	Cervical Cancer	CCLE	VRVFEE	LIG_APCC_ABBA_1	347:352	Mutation rewiring degron network	0.1389
p.D359E	ACH-001513	Cervical Cancer	CCLE	KVRVFEE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM117A

UniProt ID: Q9C073

Entrez ID: 81558

Protein name: Protein FAM117A (C/EBP-induced protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM117A in