DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRAGLQPLR
Uniprot ID:
Q9C073
Source protein:
Protein FAM117A
Source gene:
FAM117A
Class:
DEG_APCC_DBOX_1
Location:
37:45
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9807
ASA_SCORE:
83.4222
COIL:
0.7518
CONS_SCORE:
0.4706
DSS_SCORE:
0.6638
HELIX:
0.1028
FCONS_SCORE:
1.1663
RIG_SCORE:
0.6681
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P37S
DO23204
LINC
ICGC
PRAGLQPLR
DEG_APCC_DBOX_1
0.5641
p.A34T
ACH-000843
Lung Cancer
CCLE
PRAGLQPLR
DEG_APCC_DBOX_1
0.25
Drug responses associated with FAM117A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRAGLQPLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9C073
Protein FAM117A
DEG_APCC_DBOX_1
37:45
PRAGLQPLR
APC,CDC20,FZR1
0.9807
More...