DegronMD

Uniprot ID: Q9C073

Source protein: Protein FAM117A

Source gene: FAM117A

Class: LIG_APCC_ABBA_1

Location: 347:352

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9837

ASA_SCORE: 78.7667

COIL: 0.4382

CONS_SCORE: 0.6474

DSS_SCORE: 0.5032

HELIX: 0.4608

FCONS_SCORE: 0.985

RIG_SCORE: 0.795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L360V	TCGA-5S-A9Q8	UCEC	TCGA	VRVFEE	LIG_APCC_ABBA_1	0.1111
p.L360V	DO50074	UCEC	ICGC	VRVFEE	LIG_APCC_ABBA_1	0.1111
p.E345D	TCGA-EO-A22X	UCEC	TCGA	VRVFEE	LIG_APCC_ABBA_1	0.2778
p.E345D	DO43907	UCEC	ICGC	VRVFEE	LIG_APCC_ABBA_1	0.2778
p.P341S	TCGA-GN-A26A	SKCM	TCGA	VRVFEE	LIG_APCC_ABBA_1	0.1667
p.P341S	DO37861	SKCM	ICGC	VRVFEE	LIG_APCC_ABBA_1	0.1667
p.T354M	DO48388	BLCA	ICGC	VRVFEE	LIG_APCC_ABBA_1	0.7222
p.S355Y	DO232224	PBCA	ICGC	VRVFEE	LIG_APCC_ABBA_1	0.6944
p.D359E	ACH-001513	Cervical Cancer	CCLE	VRVFEE	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons