DegronMD

Uniprot ID: P98161

Source protein: Polycystin-1

Source gene: PKD1

Class: LIG_APCC_ABBA_1

Location: 1206:1211

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8618

ASA_SCORE: 55.8833

COIL: 0.1708

CONS_SCORE: 0.3328

DSS_SCORE: 0.1625

HELIX: 0.0097

FCONS_SCORE: 0.8833

RIG_SCORE: 0.9165

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1209I	DO47124	RECA	ICGC	VRVFEE	LIG_APCC_ABBA_1	0.7415
p.R1207C	DO233791	GACA	ICGC	VRVFEE	LIG_APCC_ABBA_1	0.719
p.L1212P	ACH-000978	Endometrial/Uterine Cancer	CCLE	VRVFEE	LIG_APCC_ABBA_1	0.3056
p.R1213H	SIDM00780	Colorectal Carcinoma	GDSC	VRVFEE	LIG_APCC_ABBA_1	0.2778
p.R1213H	ACH-000967	Colon/Colorectal Cancer	CCLE	VRVFEE	LIG_APCC_ABBA_1	0.2778
p.S1216G	SIDM00479	Esophageal Carcinoma	GDSC	VRVFEE	LIG_APCC_ABBA_1	0.1944
p.S1216G	ACH-000679	Esophageal Cancer	CCLE	VRVFEE	LIG_APCC_ABBA_1	0.1944
p.G1199S	SIDM00410	Other Blood Cancers	GDSC	VRVFEE	LIG_APCC_ABBA_1	0.1389
p.G1199S	ACH-002317	Leukemia	CCLE	VRVFEE	LIG_APCC_ABBA_1	0.1389
p.G1199S	YT	haematopoietic_and_lymphoid_tissue	COSMIC	VRVFEE	LIG_APCC_ABBA_1	0.1389
p.T1196M	TCGA-A5-A2K3	UCEC	TCGA	VRVFEE	LIG_APCC_ABBA_1	0.0556
p.T1196M	DO43899	UCEC	ICGC	VRVFEE	LIG_APCC_ABBA_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons