DegronMD

Uniprot ID: O60487

Source protein: Myelin protein zero-like protein 2

Source gene: MPZL2

Class: LIG_APCC_ABBAyCdc20_2

Location: 206:212

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.735

ASA_SCORE: 118.1143

COIL: 0.8319

CONS_SCORE: 0.3468

DSS_SCORE: 0.6194

HELIX: 0.1436

FCONS_SCORE: 0.7635

RIG_SCORE: 0.7943

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S208Y	TCGA-A5-A1OF	UCEC	TCGA	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.712
p.S208Y	DO42568	UCEC	ICGC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.712
p.K206R	TCGA-CM-6162	COAD	TCGA	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.6126
p.K206R	DO8479	COAD	ICGC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.6126
p.E204Q	TCGA-DK-A3IT	BLCA	TCGA	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E204Q	DO779	BLCA	ICGC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.N202S	TCGA-Z2-A8RT	SKCM	TCGA	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.N202S	DO51301	SKCM	ICGC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.N202I	DO231047	LUSC	ICGC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E199K	SIDM00392	Melanoma	GDSC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E197Q	ACH-000975	Lung Cancer	CCLE	KVSVYLE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60487	Myelin protein zero-like protein 2	LIG_APCC_ABBAyCdc20_2	206:212	KVSVYLE	APC,CDC20,FZR1	0.735	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons