DegronMD - O60487(MPZL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S208Y	TCGA-A5-A1OF	UCEC	TCGA	VSVYLE	LIG_APCC_ABBA_1	207:212	Mutation altering degron motif	0.712
p.S208Y	TCGA-A5-A1OF	UCEC	TCGA	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation altering degron motif	0.712
p.S208Y	DO42568	UCEC	ICGC	VSVYLE	LIG_APCC_ABBA_1	207:212	Mutation altering degron motif	0.712
p.S208Y	DO42568	UCEC	ICGC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation altering degron motif	0.712
p.K206R	TCGA-CM-6162	COAD	TCGA	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation altering degron motif	0.6126
p.K206R	DO8479	COAD	ICGC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation altering degron motif	0.6126
p.E204Q	TCGA-DK-A3IT	BLCA	TCGA	VSVYLE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.25
p.E204Q	TCGA-DK-A3IT	BLCA	TCGA	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation rewiring degron network	0.2778
p.E204Q	DO779	BLCA	ICGC	VSVYLE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.25
p.E204Q	DO779	BLCA	ICGC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation rewiring degron network	0.2778
p.N202S	TCGA-Z2-A8RT	SKCM	TCGA	VSVYLE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.1944
p.N202S	TCGA-Z2-A8RT	SKCM	TCGA	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation rewiring degron network	0.2222
p.N202S	DO51301	SKCM	ICGC	VSVYLE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.1944
p.N202S	DO51301	SKCM	ICGC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation rewiring degron network	0.2222
p.N202I	DO231047	LUSC	ICGC	VSVYLE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.1944
p.N202I	DO231047	LUSC	ICGC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation rewiring degron network	0.2222
p.E199K	SIDM00392	Melanoma	GDSC	VSVYLE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.1111
p.E199K	SIDM00392	Melanoma	GDSC	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation rewiring degron network	0.1389
p.E197Q	ACH-000975	Lung Cancer	CCLE	VSVYLE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.0556
p.E197Q	ACH-000975	Lung Cancer	CCLE	KVSVYLE	LIG_APCC_ABBAyCdc20_2	206:212	Mutation rewiring degron network	0.0833

Kaplan plot for MPZL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPZL2

UniProt ID: O60487

Entrez ID: 10205

Protein name: Myelin protein zero-like protein 2 (Epithelial V-like antigen 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPZL2 in