DegronMD

Uniprot ID: O60487

Source protein: Myelin protein zero-like protein 2

Source gene: MPZL2

Class: LIG_APCC_ABBA_1

Location: 207:212

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7101

ASA_SCORE: 113.2167

COIL: 0.842

CONS_SCORE: 0.3418

DSS_SCORE: 0.6435

HELIX: 0.1325

FCONS_SCORE: 0.7799

RIG_SCORE: 0.7966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S208Y	TCGA-A5-A1OF	UCEC	TCGA	VSVYLE	LIG_APCC_ABBA_1	0.712
p.S208Y	DO42568	UCEC	ICGC	VSVYLE	LIG_APCC_ABBA_1	0.712
p.E204Q	TCGA-DK-A3IT	BLCA	TCGA	VSVYLE	LIG_APCC_ABBA_1	0.25
p.E204Q	DO779	BLCA	ICGC	VSVYLE	LIG_APCC_ABBA_1	0.25
p.N202S	TCGA-Z2-A8RT	SKCM	TCGA	VSVYLE	LIG_APCC_ABBA_1	0.1944
p.N202S	DO51301	SKCM	ICGC	VSVYLE	LIG_APCC_ABBA_1	0.1944
p.N202I	DO231047	LUSC	ICGC	VSVYLE	LIG_APCC_ABBA_1	0.1944
p.E199K	SIDM00392	Melanoma	GDSC	VSVYLE	LIG_APCC_ABBA_1	0.1111
p.E197Q	ACH-000975	Lung Cancer	CCLE	VSVYLE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60487	Myelin protein zero-like protein 2	LIG_APCC_ABBA_1	207:212	VSVYLE	APC,CDC20,FZR1	0.7101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons