DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
KVTLHKD
Uniprot ID:
Q9C0E4
Source protein:
Glutamate receptor-interacting protein 2
Source gene:
GRIP2
Class:
LIG_APCC_ABBAyCdc20_2
Location:
941:947
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.504
ASA_SCORE:
56
COIL:
0.4549
CONS_SCORE:
0.5857
DSS_SCORE:
0.3731
HELIX:
0.0431
FCONS_SCORE:
1.0277
RIG_SCORE:
0.7618
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GRIP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KVTLHKD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9C0E4
Glutamate receptor-interacting protein 2
LIG_APCC_ABBAyCdc20_2
941:947
KVTLHKD
APC,CDC20,FZR1
0.504
More...