DegronMD

Uniprot ID: P11171

Source protein: Protein 4.1

Source gene: EPB41

Class: LIG_APCC_ABBAyCdc20_2

Location: 852:858

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9622

ASA_SCORE: 83.2286

COIL: 0.2096

CONS_SCORE: 0.553

DSS_SCORE: 0.564

HELIX: 0.0123

FCONS_SCORE: 1.0733

RIG_SCORE: 0.8053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E860K	TCGA-A5-A0G2	UCEC	TCGA	KVVVHQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q857K	TCGA-D3-A2JC	SKCM	TCGA	KVVVHQE	LIG_APCC_ABBAyCdc20_2	0.5833
p.D863G	SIDM01664	Prostate Carcinoma	GDSC	KVVVHQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D863G	ACH-000952	Prostate Cancer	CCLE	KVVVHQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K852N	SIDM01494	Glioblastoma	GDSC	KVVVHQE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K852N	ACH-000445	Brain Cancer	CCLE	KVVVHQE	LIG_APCC_ABBAyCdc20_2	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11171	Protein 4.1	LIG_APCC_ABBAyCdc20_2	852:858	KVVVHQE	APC,CDC20,FZR1	0.9622	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons