DegronMD

Uniprot ID: Q96GA3

Source protein: Protein LTV1 homolog

Source gene: LTV1

Class: LIG_APCC_ABBAyCdc20_2

Location: 57:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9976

ASA_SCORE: 70.5286

COIL: 0.7351

CONS_SCORE: 0.4459

DSS_SCORE: 0.3797

HELIX: 0.2166

FCONS_SCORE: 1.0094

RIG_SCORE: 0.7996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D65Y	TCGA-22-4609	LUSC	TCGA	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D65Y	DO229018	LICA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D65Y	DO26838	LUSC	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.K73N	TCGA-AP-A1DV	UCEC	TCGA	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.5
p.K73N	DO43186	UCEC	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.5
p.Y66C	TCGA-XF-A9ST	BLCA	TCGA	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.6944
p.Y66C	DO223599	BLCA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.6944
p.D47H	DO1172	BRCA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E49K	DO1110	BRCA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.N48S	DO223504	CLLE	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E49D	DO233885	GACA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.L72Q	DO44858	LICA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D63N	DO50805	LIRI	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.6932
p.K57T	DO50805	LIRI	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.7306
p.D64G	SIDM00121	T-Lymphoblastic Leukemia	GDSC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D64G	ACH-001738	Leukemia	CCLE	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D64G	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96GA3	Protein LTV1 homolog	LIG_APCC_ABBAyCdc20_2	57:63	KYGVFFD	APC,CDC20,FZR1	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons