DegronMD - Q96GA3(LTV1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D65Y	TCGA-22-4609	LUSC	TCGA	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.2778
p.D65Y	DO229018	LICA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.2778
p.D65Y	DO26838	LUSC	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.2778
p.D271N	TCGA-86-7953	LUAD	TCGA	LTLHDE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0556
p.D271N	DO24090	LUAD	ICGC	LTLHDE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0556
p.L256Q	TCGA-AG-A02X	READ	TCGA	LTLHDE	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.7765
p.K73N	TCGA-AP-A1DV	UCEC	TCGA	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation blocking ubiquitination signal	0.5
p.K73N	DO43186	UCEC	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation blocking ubiquitination signal	0.5
p.E264Q	TCGA-DK-A2I1	BLCA	TCGA	LTLHDE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.25
p.E264Q	DO444	BLCA	ICGC	LTLHDE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.25
p.Y66C	TCGA-XF-A9ST	BLCA	TCGA	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation blocking phosphorylation signal	0.6944
p.Y66C	DO223599	BLCA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation blocking phosphorylation signal	0.6944
p.D47H	DO1172	BRCA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0556
p.E49K	DO1110	BRCA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.1111
p.N48S	DO223504	CLLE	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0833
p.R252K	DO233724	GACA	ICGC	LTLHDE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2222
p.E49D	DO233885	GACA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.1111
p.L72Q	DO44858	LICA	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0833
p.D63N	DO50805	LIRI	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation altering degron motif	0.6932
p.K57T	DO50805	LIRI	ICGC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation altering degron motif	0.7306
p.D64G	SIDM00121	T-Lymphoblastic Leukemia	GDSC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.D64G	ACH-001738	Leukemia	CCLE	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.D64G	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	KYGVFFD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056

Kaplan plot for LTV1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LTV1

UniProt ID: Q96GA3

Entrez ID: 84946

Protein name: Protein LTV1 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LTV1 in