DegronMD

Uniprot ID: Q96GA3

Source protein: Protein LTV1 homolog

Source gene: LTV1

Class: LIG_APCC_ABBA_1

Location: 256:261

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9088

ASA_SCORE: 69.5833

COIL: 0.1123

CONS_SCORE: 0.6538

DSS_SCORE: 0.3321

HELIX: 0.8792

FCONS_SCORE: 1.1218

RIG_SCORE: 0.7958

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D271N	TCGA-86-7953	LUAD	TCGA	LTLHDE	LIG_APCC_ABBA_1	0.0556
p.D271N	DO24090	LUAD	ICGC	LTLHDE	LIG_APCC_ABBA_1	0.0556
p.L256Q	TCGA-AG-A02X	READ	TCGA	LTLHDE	LIG_APCC_ABBA_1	0.7765
p.E264Q	TCGA-DK-A2I1	BLCA	TCGA	LTLHDE	LIG_APCC_ABBA_1	0.25
p.E264Q	DO444	BLCA	ICGC	LTLHDE	LIG_APCC_ABBA_1	0.25
p.R252K	DO233724	GACA	ICGC	LTLHDE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96GA3	Protein LTV1 homolog	LIG_APCC_ABBA_1	256:261	LTLHDE	APC,CDC20,FZR1	0.9088	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons