DegronMD

Uniprot ID: Q12766

Source protein: HMG domain-containing protein 3

Source gene: HMGXB3

Class: LIG_APCC_ABBAyCdc20_2

Location: 34:40

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5736

ASA_SCORE: 126.8143

COIL: 0.929

CONS_SCORE: 0.1205

DSS_SCORE: 0.5014

HELIX: 0.0474

FCONS_SCORE: 1

RIG_SCORE: 0.7598

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K30N	TCGA-AP-A1DV	UCEC	TCGA	KYKIHGE	LIG_APCC_ABBAyCdc20_2	0.3333
p.K30N	DO43186	UCEC	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	0.3333
p.K44T	TCGA-CA-6717	COAD	TCGA	KYKIHGE	LIG_APCC_ABBAyCdc20_2	0.3333
p.K44T	DO8264	COAD	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	0.3333
p.E40Q	DO225140	BRCA	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	0.6744
p.E40G	DO228978	LICA	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	0.7199
p.R46S	DO229009	LICA	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.Y49H	DO229229	THCA	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12766	HMG domain-containing protein 3	LIG_APCC_ABBAyCdc20_2	34:40	KYKIHGE	APC,CDC20,FZR1	0.5736	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons