DegronMD - Q12766(HMGXB3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K30N	TCGA-AP-A1DV	UCEC	TCGA	KYKIHGE	LIG_APCC_ABBAyCdc20_2	34:40	Mutation substituting flanking lysine	0.3333
p.K30N	DO43186	UCEC	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	34:40	Mutation substituting flanking lysine	0.3333
p.K44T	TCGA-CA-6717	COAD	TCGA	KYKIHGE	LIG_APCC_ABBAyCdc20_2	34:40	Mutation substituting flanking lysine	0.3333
p.K44T	DO8264	COAD	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	34:40	Mutation substituting flanking lysine	0.3333
p.S394L	TCGA-D5-6540	COAD	TCGA	SKENA	DEG_APCC_KENBOX_2	382:386	Mutation rewiring degron network	0.1111
p.S394L	DO9708	COAD	ICGC	SKENA	DEG_APCC_KENBOX_2	382:386	Mutation rewiring degron network	0.1111
p.E40Q	DO225140	BRCA	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	34:40	Mutation altering degron motif	0.6744
p.G101C	DO234350	ESAD	ICGC	SALTAVVPDI	DEG_COP1_1	109:118	Mutation rewiring degron network	0.1111
p.E40G	DO228978	LICA	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	34:40	Mutation altering degron motif	0.7199
p.R46S	DO229009	LICA	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	34:40	Mutation rewiring degron network	0.1667
p.Y49H	DO229229	THCA	ICGC	KYKIHGE	LIG_APCC_ABBAyCdc20_2	34:40	Mutation rewiring degron network	0.0833
p.P126S	SIDM00596	Endometrial Carcinoma	GDSC	SALTAVVPDI	DEG_COP1_1	109:118	Mutation rewiring degron network	0.1111
p.P126S	ACH-001517	Endometrial/Uterine Cancer	CCLE	SALTAVVPDI	DEG_COP1_1	109:118	Mutation rewiring degron network	0.1111
p.P126S	HEC-1	endometrium	COSMIC	SALTAVVPDI	DEG_COP1_1	109:118	Mutation rewiring degron network	0.1111
p.P116Q	SIDM00220	Ovarian Carcinoma	GDSC	SALTAVVPDI	DEG_COP1_1	109:118	Mutation altering degron motif	0.7035
p.P116Q	ACH-000962	Ovarian Cancer	CCLE	SALTAVVPDI	DEG_COP1_1	109:118	Mutation altering degron motif	0.7035
p.P116Q	ACH-001145	Ovarian Cancer	CCLE	SALTAVVPDI	DEG_COP1_1	109:118	Mutation altering degron motif	0.7035
p.P116Q	OC-314	ovary	COSMIC	SALTAVVPDI	DEG_COP1_1	109:118	Mutation altering degron motif	0.7035
p.E378K	ACH-002042	Thyroid Cancer	CCLE	SKENA	DEG_APCC_KENBOX_2	382:386	Mutation rewiring degron network	0.2222
p.S389I	EN	endometrium	COSMIC	SKENA	DEG_APCC_KENBOX_2	382:386	Mutation rewiring degron network	0.25
p.S389I	YKG-1	central nervous system	COSMIC	SKENA	DEG_APCC_KENBOX_2	382:386	Mutation rewiring degron network	0.25
p.S389I	KY821	haematopoietic and lymphoid tissue	COSMIC	SKENA	DEG_APCC_KENBOX_2	382:386	Mutation rewiring degron network	0.25
p.S389I	KINGS-1	central nervous system	COSMIC	SKENA	DEG_APCC_KENBOX_2	382:386	Mutation rewiring degron network	0.25
p.P372S	HEC-1	endometrium	COSMIC	SKENA	DEG_APCC_KENBOX_2	382:386	Mutation rewiring degron network	0.0556
p.R388W	PA-1	ovary	COSMIC	SKENA	DEG_APCC_KENBOX_2	382:386	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HMGXB3

UniProt ID: Q12766

Entrez ID: 22993

Protein name: HMG domain-containing protein 3 (HMG box-containing protein 3) (Protein SMF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HMGXB3 in