DegronMD

Uniprot ID: Q12766

Source protein: HMG domain-containing protein 3

Source gene: HMGXB3

Class: DEG_COP1_1

Location: 109:118

E3 ligase: COP1

DEGRON score: 0.7075

ASA_SCORE: 79.2

COIL: 0.8665

CONS_SCORE: 0.1207

DSS_SCORE: 0.2063

HELIX: 0.0963

FCONS_SCORE: 0.8987

RIG_SCORE: 0.8096

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G101C	DO234350	ESAD	ICGC	SALTAVVPDI	DEG_COP1_1	0.1111
p.P126S	SIDM00596	Endometrial Carcinoma	GDSC	SALTAVVPDI	DEG_COP1_1	0.1111
p.P126S	ACH-001517	Endometrial/Uterine Cancer	CCLE	SALTAVVPDI	DEG_COP1_1	0.1111
p.P126S	HEC-1	endometrium	COSMIC	SALTAVVPDI	DEG_COP1_1	0.1111
p.P116Q	SIDM00220	Ovarian Carcinoma	GDSC	SALTAVVPDI	DEG_COP1_1	0.7035
p.P116Q	ACH-000962	Ovarian Cancer	CCLE	SALTAVVPDI	DEG_COP1_1	0.7035
p.P116Q	ACH-001145	Ovarian Cancer	CCLE	SALTAVVPDI	DEG_COP1_1	0.7035
p.P116Q	OC-314	ovary	COSMIC	SALTAVVPDI	DEG_COP1_1	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12766	HMG domain-containing protein 3	DEG_COP1_1	109:118	SALTAVVPDI	COP1	0.7075	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons