DegronMD

Uniprot ID: Q12766

Source protein: HMG domain-containing protein 3

Source gene: HMGXB3

Class: DEG_APCC_KENBOX_2

Location: 382:386

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7913

ASA_SCORE: 102.78

COIL: 0.7392

CONS_SCORE: 0.5411

DSS_SCORE: 0.6244

HELIX: 0.2428

FCONS_SCORE: 0.9097

RIG_SCORE: 0.6662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S394L	TCGA-D5-6540	COAD	TCGA	SKENA	DEG_APCC_KENBOX_2	0.1111
p.S394L	DO9708	COAD	ICGC	SKENA	DEG_APCC_KENBOX_2	0.1111
p.E378K	ACH-002042	Thyroid Cancer	CCLE	SKENA	DEG_APCC_KENBOX_2	0.2222
p.S389I	EN	endometrium	COSMIC	SKENA	DEG_APCC_KENBOX_2	0.25
p.S389I	YKG-1	central_nervous_system	COSMIC	SKENA	DEG_APCC_KENBOX_2	0.25
p.S389I	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	SKENA	DEG_APCC_KENBOX_2	0.25
p.S389I	KINGS-1	central_nervous_system	COSMIC	SKENA	DEG_APCC_KENBOX_2	0.25
p.P372S	HEC-1	endometrium	COSMIC	SKENA	DEG_APCC_KENBOX_2	0.0556
p.R388W	PA-1	ovary	COSMIC	SKENA	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_APCC_KENBOX_2	202:206	SKENA	APC,CDC20,FZR1	0.971	More...
Q12766	HMG domain-containing protein 3	DEG_APCC_KENBOX_2	382:386	SKENA	APC,CDC20,FZR1	0.7913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons