DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SKENA
Uniprot ID:
Q8WXI7
Source protein:
Mucin-16
Source gene:
MUC16
Class:
DEG_APCC_KENBOX_2
Location:
202:206
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.971
ASA_SCORE:
108.98
COIL:
0.8938
CONS_SCORE:
0
DSS_SCORE:
0.5649
HELIX:
0.0344
FCONS_SCORE:
0
RIG_SCORE:
0.6573
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P192L
TCGA-18-3409
LUSC
TCGA
SKENA
DEG_APCC_KENBOX_2
0.0556
p.P192L
DO26444
LUSC
ICGC
SKENA
DEG_APCC_KENBOX_2
0.0556
p.M193I
TCGA-EE-A2MR
SKCM
TCGA
SKENA
DEG_APCC_KENBOX_2
0.0833
p.M193I
DO222868
MELA
ICGC
SKENA
DEG_APCC_KENBOX_2
0.0833
p.M193I
DO37819
SKCM
ICGC
SKENA
DEG_APCC_KENBOX_2
0.0833
p.P192S
DO222501
COCA
ICGC
SKENA
DEG_APCC_KENBOX_2
0.0556
p.S202F
DO220872
MELA
ICGC
SKENA
DEG_APCC_KENBOX_2
0.7982
Drug responses associated with MUC16 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SKENA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WXI7
Mucin-16
DEG_APCC_KENBOX_2
202:206
SKENA
APC,CDC20,FZR1
0.971
More...
Q12766
HMG domain-containing protein 3
DEG_APCC_KENBOX_2
382:386
SKENA
APC,CDC20,FZR1
0.7913
More...