DegronMD

Uniprot ID: Q86UR5

Source protein: Regulating synaptic membrane exocytosis protein 1

Source gene: RIMS1

Class: LIG_APCC_ABBAyCdc20_2

Location: 1321:1327

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6133

ASA_SCORE: 112.8714

COIL: 0.7851

CONS_SCORE: 0.359

DSS_SCORE: 0.4803

HELIX: 0.1806

FCONS_SCORE: 0.9437

RIG_SCORE: 0.7725

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1327N	TCGA-EY-A1H0	UCEC	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.6932
p.I1324M	TCGA-B5-A3FC	UCEC	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.6507
p.S1320F	TCGA-DD-A3A9	LIHC	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q1328R	TCGA-FA-A86F	DLBC	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S1328P	SNU-1040	large_intestine	COSMIC	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.I1317N	SW1783	central_nervous_system	COSMIC	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R1316C	TCGA-06-5416	GBM	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R1316C	SIDM01293	Colorectal Carcinoma	GDSC	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R1316H	TCGA-AZ-6606	COAD	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.S1336F	ACH-001413	Bladder Cancer	CCLE	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S1312T	NCI-H2342	lung	COSMIC	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1336Q	SNG-M	endometrium	COSMIC	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A1337T	TCGA-D1-A1NZ	UCEC	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UR5	Regulating synaptic membrane exocytosis protein 1	LIG_APCC_ABBAyCdc20_2	1321:1327	KYNIHKD	APC,CDC20,FZR1	0.6133	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons