DegronMD - Q86UR5(RIMS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1316C	TCGA-06-5416	GBM	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.1944
p.R1316C	SIDM01293	Colorectal Carcinoma	GDSC	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.1944
p.S967T	TCGA-22-5479	LUSC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.7116
p.E552Q	TCGA-5P-A9K2	KIRP	TCGA	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.1111
p.E552Q	DO223947	KIRP	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.1111
p.R958L	TCGA-60-2704	LUSC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.S955Y	TCGA-62-A46P	LUAD	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.0556
p.K896N	TCGA-A6-3808	COAD	TCGA	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation substituting flanking lysine	0.3333
p.K896N	DO8408	COAD	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation substituting flanking lysine	0.3333
p.R968C	TCGA-AB-2959	LAML	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.719
p.R968C	TCGA-XK-AAIW	PRAD	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.719
p.P973T	TCGA-AP-A056	UCEC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.5919
p.R887Q	TCGA-AX-A0J0	UCEC	TCGA	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation altering degron motif	0.6218
p.R887Q	DO41133	UCEC	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation altering degron motif	0.6218
p.R887Q	ACH-001270	Sarcoma	CCLE	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation altering degron motif	0.6218
p.R958H	TCGA-AX-A2HC	UCEC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R958H	TCGA-VQ-A924	STAD	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R958H	SIDM00789	Colorectal Carcinoma	GDSC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R958H	ACH-000997	Colon/Colorectal Cancer	CCLE	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R958H	ACH-001061	Colon/Colorectal Cancer	CCLE	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R958H	HCT-15	large intestine	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R1316H	TCGA-AZ-6606	COAD	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.1944
p.I1324M	TCGA-B5-A3FC	UCEC	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation altering degron motif	0.6507
p.P973S	TCGA-BS-A0UF	UCEC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.5641
p.S531I	TCGA-CL-4957	READ	TCGA	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.1389
p.S531I	DO36439	READ	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.1389
p.A1337T	TCGA-D1-A1NZ	UCEC	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.0556
p.E980K	TCGA-D3-A8GO	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.E980K	TCGA-GF-A6C9	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.E892K	TCGA-D6-6516	HNSC	TCGA	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation altering degron motif	0.7022
p.E892K	DO15623	HNSC	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation altering degron motif	0.7022
p.P983S	TCGA-D6-6824	HNSC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.0556
p.G963E	TCGA-D9-A6EC	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.2778
p.S1320F	TCGA-DD-A3A9	LIHC	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.3056
p.S955P	TCGA-DD-AADO	LIHC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.0556
p.P541L	TCGA-DM-A0X9	COAD	TCGA	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation altering degron motif	0.7582
p.P541L	DO8618	COAD	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation altering degron motif	0.7582
p.R958C	TCGA-EB-A3Y7	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R958C	TCGA-FS-A4F9	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R958C	TCGA-GN-A266	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.P970Q	TCGA-EE-A183	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.5924
p.D961N	TCGA-EE-A2MI	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.2222
p.R966C	TCGA-EJ-A65D	PRAD	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.H890N	TCGA-EO-A22U	UCEC	TCGA	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation altering degron motif	0.7423
p.H890N	DO222884	COCA	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation altering degron motif	0.7423
p.H890N	DO43755	UCEC	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation altering degron motif	0.7423
p.K897Q	TCGA-EO-A3AV	UCEC	TCGA	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation substituting flanking lysine	0.3056
p.K897Q	DO52412	UCEC	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation substituting flanking lysine	0.3056
p.D1327N	TCGA-EY-A1H0	UCEC	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation altering degron motif	0.6932
p.Q1328R	TCGA-FA-A86F	DLBC	TCGA	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.3056
p.P983A	TCGA-FD-A43P	BLCA	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.0556
p.G963R	TCGA-XF-A8HB	BLCA	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.2778
p.G962R	DO51907	BLCA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.25
p.P982A	DO44049	BLCA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.0833
p.R965C	DO227971	COCA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.R965C	DO49752	PRAD	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.R967C	DO234270	ESAD	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.R967C	DO21107	LAML	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.R967C	DO35212	PACA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.R967C	DO51407	PRAD	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.M528R	DO233905	GACA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.0556
p.P982S	DO15967	HNSC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.0833
p.S551I	DO229015	LICA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.1389
p.S551I	DO43306	UCEC	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.1389
p.Q902H	DO229022	LICA	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation rewiring degron network	0.0556
p.R542S	DO229009	LICA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation altering degron motif	0.7427
p.R545K	DO23846	LUAD	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.3056
p.S901F	DO26934	LUSC	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation rewiring degron network	0.0833
p.R957L	DO26555	LUSC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.S966T	DO27287	LUSC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.7116
p.E547K	DO228376	MALY	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.25
p.E535K	DO220877	MELA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.25
p.R886K	DO222653	MELA	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation altering degron motif	0.6126
p.S539L	DO227557	ORCA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation altering degron motif	0.6556
p.R549I	DO35132	PACA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.1944
p.R965H	DO51536	PACA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8244
p.R965H	DO229240	THCA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8244
p.H890Y	DO229502	SKCA	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation altering degron motif	0.6118
p.D960N	DO37531	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1944
p.P969Q	DO37715	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.7035
p.R957C	DO37499	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.R957C	DO37432	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.R957C	DO38069	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.G962E	DO50291	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.25
p.E979K	DO51254	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1667
p.E979K	DO51242	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1667
p.R957H	DO51795	STAD	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.R957H	DO41572	UCEC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.R957H	HCT-15	large intestine	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.S547Y	DO42312	UCEC	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.25
p.R545I	DO42873	UCEC	ICGC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.3056
p.P972S	DO41488	UCEC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.6752
p.P972T	DO43971	UCEC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.7031
p.R958P	SIDM00189	Melanoma	GDSC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R958P	ACH-002098	Skin Cancer	CCLE	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R958P	CP67-MEL	skin	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.G959S	SIDM00217	Colorectal Carcinoma	GDSC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1667
p.G959S	ACH-000999	Colon/Colorectal Cancer	CCLE	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1667
p.G959S	SNU-1040	large intestine	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1667
p.S1336F	ACH-001413	Bladder Cancer	CCLE	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.0833
p.G958S	SNU-1040	large intestine	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.I1317N	SW1783	central nervous system	COSMIC	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.2222
p.M544I	IST-SL2	lung	COSMIC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation altering degron motif	0.7618
p.S1312T	NCI-H2342	lung	COSMIC	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.0833
p.R957P	CP67-MEL	skin	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.S969P	SNU-1040	large intestine	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.6752
p.S982T	NCI-H2342	lung	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.0833
p.S1328P	SNU-1040	large intestine	COSMIC	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.3056
p.M553I	IST-SL2	lung	COSMIC	VSTPEYT	DEG_SCF_FBW7_1	538:544	Mutation rewiring degron network	0.0833
p.R1336Q	SNG-M	endometrium	COSMIC	KYNIHKD	LIG_APCC_ABBAyCdc20_2	1321:1327	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIMS1

UniProt ID: Q86UR5

Entrez ID: 22999

Protein name: Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIMS1 in