DegronMD

Uniprot ID: Q86UR5

Source protein: Regulating synaptic membrane exocytosis protein 1

Source gene: RIMS1

Class: DEG_APCC_DBOX_1

Location: 965:973

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9944

ASA_SCORE: 99.1

COIL: 0.9259

CONS_SCORE: 0.4466

DSS_SCORE: 0.8271

HELIX: 0.0299

FCONS_SCORE: 1.1228

RIG_SCORE: 0.6126

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S967T	TCGA-22-5479	LUSC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.7116
p.R958L	TCGA-60-2704	LUSC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.S955Y	TCGA-62-A46P	LUAD	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.0556
p.R968C	TCGA-AB-2959	LAML	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.719
p.R968C	TCGA-XK-AAIW	PRAD	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.719
p.P973T	TCGA-AP-A056	UCEC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.5919
p.R958H	TCGA-AX-A2HC	UCEC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.R958H	TCGA-VQ-A924	STAD	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.R958H	SIDM00789	Colorectal Carcinoma	GDSC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.R958H	ACH-000997	Colon/Colorectal Cancer	CCLE	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.R958H	ACH-001061	Colon/Colorectal Cancer	CCLE	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.R958H	HCT-15	large_intestine	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.P973S	TCGA-BS-A0UF	UCEC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.5641
p.E980K	TCGA-D3-A8GO	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.E980K	TCGA-GF-A6C9	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.P983S	TCGA-D6-6824	HNSC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.0556
p.G963E	TCGA-D9-A6EC	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.2778
p.S955P	TCGA-DD-AADO	LIHC	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.0556
p.R958C	TCGA-EB-A3Y7	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.R958C	TCGA-FS-A4F9	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.R958C	TCGA-GN-A266	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.P970Q	TCGA-EE-A183	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.5924
p.D961N	TCGA-EE-A2MI	SKCM	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.2222
p.R966C	TCGA-EJ-A65D	PRAD	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.8301
p.P983A	TCGA-FD-A43P	BLCA	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.0556
p.G963R	TCGA-XF-A8HB	BLCA	TCGA	PRSRLPNVP	DEG_APCC_DBOX_1	0.2778
p.G962R	DO51907	BLCA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.25
p.P982A	DO44049	BLCA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.0833
p.R965C	DO227971	COCA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.8301
p.R965C	DO49752	PRAD	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.8301
p.R967C	DO234270	ESAD	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.8301
p.R967C	DO21107	LAML	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.8301
p.R967C	DO35212	PACA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.8301
p.R967C	DO51407	PRAD	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.8301
p.P982S	DO15967	HNSC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.0833
p.R957L	DO26555	LUSC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1111
p.S966T	DO27287	LUSC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.7116
p.R965H	DO51536	PACA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.8244
p.R965H	DO229240	THCA	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.8244
p.D960N	DO37531	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1944
p.P969Q	DO37715	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.7035
p.R957C	DO37499	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1111
p.R957C	DO37432	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1111
p.R957C	DO38069	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1111
p.G962E	DO50291	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.25
p.E979K	DO51254	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1667
p.E979K	DO51242	SKCM	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1667
p.R957H	DO51795	STAD	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1111
p.R957H	DO41572	UCEC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1111
p.R957H	HCT-15	large_intestine	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1111
p.P972S	DO41488	UCEC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.6752
p.P972T	DO43971	UCEC	ICGC	PRSRLPNVP	DEG_APCC_DBOX_1	0.7031
p.R958P	SIDM00189	Melanoma	GDSC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.R958P	ACH-002098	Skin Cancer	CCLE	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.R958P	CP67-MEL	skin	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.G959S	SIDM00217	Colorectal Carcinoma	GDSC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1667
p.G959S	ACH-000999	Colon/Colorectal Cancer	CCLE	PRSRLPNVP	DEG_APCC_DBOX_1	0.1667
p.G959S	SNU-1040	large_intestine	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1667
p.G958S	SNU-1040	large_intestine	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1389
p.R957P	CP67-MEL	skin	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	0.1111
p.S969P	SNU-1040	large_intestine	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	0.6752
p.S982T	NCI-H2342	lung	COSMIC	PRSRLPNVP	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSRLPNVP

Degron related mutations and impact score

Drug responses associated with RIMS1 mutations

All proteins holding degron of PRSRLPNVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UR5	Regulating synaptic membrane exocytosis protein 1	DEG_APCC_DBOX_1	965:973	PRSRLPNVP	APC,CDC20,FZR1	0.9944	More...