DegronMD

Uniprot ID: Q86UR5

Source protein: Regulating synaptic membrane exocytosis protein 1

Source gene: RIMS1

Class: DEG_SCF_FBW7_1

Location: 538:544

E3 ligase: FBXW7

DEGRON score: 0.9732

ASA_SCORE: 76.2714

COIL: 0.8356

CONS_SCORE: 0.3971

DSS_SCORE: 0.6031

HELIX: 0.0824

FCONS_SCORE: 0.9033

RIG_SCORE: 0.6623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E552Q	TCGA-5P-A9K2	KIRP	TCGA	VSTPEYT	DEG_SCF_FBW7_1	0.1111
p.E552Q	DO223947	KIRP	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.1111
p.S531I	TCGA-CL-4957	READ	TCGA	VSTPEYT	DEG_SCF_FBW7_1	0.1389
p.S531I	DO36439	READ	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.1389
p.P541L	TCGA-DM-A0X9	COAD	TCGA	VSTPEYT	DEG_SCF_FBW7_1	0.7582
p.P541L	DO8618	COAD	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.7582
p.M528R	DO233905	GACA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.0556
p.S551I	DO229015	LICA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.1389
p.S551I	DO43306	UCEC	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.1389
p.R542S	DO229009	LICA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.7427
p.R545K	DO23846	LUAD	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.3056
p.E547K	DO228376	MALY	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.25
p.E535K	DO220877	MELA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.25
p.S539L	DO227557	ORCA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.6556
p.R549I	DO35132	PACA	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.1944
p.S547Y	DO42312	UCEC	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.25
p.R545I	DO42873	UCEC	ICGC	VSTPEYT	DEG_SCF_FBW7_1	0.3056
p.M544I	IST-SL2	lung	COSMIC	VSTPEYT	DEG_SCF_FBW7_1	0.7618
p.M553I	IST-SL2	lung	COSMIC	VSTPEYT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UR5	Regulating synaptic membrane exocytosis protein 1	DEG_SCF_FBW7_1	538:544	VSTPEYT	FBXW7	0.9732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons