DegronMD

Uniprot ID: Q86UR5

Source protein: Regulating synaptic membrane exocytosis protein 1

Source gene: RIMS1

Class: LIG_APCC_ABBAyCdc20_2

Location: 886:892

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7873

ASA_SCORE: 102.6429

COIL: 0.8197

CONS_SCORE: 0.4269

DSS_SCORE: 0.703

HELIX: 0.1043

FCONS_SCORE: 1.0604

RIG_SCORE: 0.6242

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K896N	TCGA-A6-3808	COAD	TCGA	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.3333
p.K896N	DO8408	COAD	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.3333
p.R887Q	TCGA-AX-A0J0	UCEC	TCGA	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R887Q	DO41133	UCEC	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R887Q	ACH-001270	Sarcoma	CCLE	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.6218
p.E892K	TCGA-D6-6516	HNSC	TCGA	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E892K	DO15623	HNSC	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.7022
p.H890N	TCGA-EO-A22U	UCEC	TCGA	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.7423
p.H890N	DO222884	COCA	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.7423
p.H890N	DO43755	UCEC	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.7423
p.K897Q	TCGA-EO-A3AV	UCEC	TCGA	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K897Q	DO52412	UCEC	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q902H	DO229022	LICA	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S901F	DO26934	LUSC	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R886K	DO222653	MELA	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.6126
p.H890Y	DO229502	SKCA	ICGC	RRHIHGE	LIG_APCC_ABBAyCdc20_2	0.6118

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UR5	Regulating synaptic membrane exocytosis protein 1	LIG_APCC_ABBAyCdc20_2	886:892	RRHIHGE	APC,CDC20,FZR1	0.7873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons