DegronMD

Uniprot ID: Q9H869

Source protein: YY1-associated protein 1

Source gene: YY1AP1

Class: DEG_SCF_FBW7_1

Location: 40:47

E3 ligase: FBXW7

DEGRON score: 0.9941

ASA_SCORE: 70.6875

COIL: 0.8543

CONS_SCORE: 0.4667

DSS_SCORE: 0.483

HELIX: 0.077

FCONS_SCORE: 0.9149

RIG_SCORE: 0.6426

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S30T	TCGA-DX-A1L2	SARC	TCGA	LAATPSSS	DEG_SCF_FBW7_1	0.5
p.S30T	DO219951	SARC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	0.5
p.S30T	ACH-000978	Endometrial/Uterine Cancer	CCLE	LAATPSSS	DEG_SCF_FBW7_1	0.5
p.S30T	EN	endometrium	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	0.5
p.R55L	TCGA-EK-A3GK	CESC	TCGA	LAATPSSS	DEG_SCF_FBW7_1	0.1111
p.R55L	DO49964	CESC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	0.1111
p.N34K	DO10880	GBM	ICGC	LAATPSSS	DEG_SCF_FBW7_1	0.1667
p.N34K	HCE-4	oesophagus	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	0.1667
p.R42W	DO22237	LGG	ICGC	LAATPSSS	DEG_SCF_FBW7_1	0.8634
p.H55Y	DO44832	LICA	ICGC	LAATPSSS	DEG_SCF_FBW7_1	0.1111
p.E53G	DO231563	LINC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	0.1667
p.F43V	DO46657	PAAD	ICGC	LAATPSSS	DEG_SCF_FBW7_1	0.7068
p.E53D	DO46901	RECA	ICGC	LAATPSSS	DEG_SCF_FBW7_1	0.1667
p.L46P	DO41903	UCEC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	0.7582
p.R42L	DO41999	UCEC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	0.8428
p.P40L	SIDM00234	Other Solid Cancers	GDSC	LAATPSSS	DEG_SCF_FBW7_1	0.7582
p.P40L	TC-YIK	cervix	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	0.7582
p.S31T	SIDM01203	Other Solid Cancers	GDSC	LAATPSSS	DEG_SCF_FBW7_1	0.0833
p.S31T	NTERA-2_cl_D1	testis	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	0.0833
p.P49T	ACH-000093	Pancreatic Cancer	CCLE	LAATPSSS	DEG_SCF_FBW7_1	0.2778
p.A42P	ACH-001338	Neuroblastoma	CCLE	LAATPSSS	DEG_SCF_FBW7_1	0.6392
p.A42P	CHP-134	autonomic_ganglia	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	0.6392
p.A41T	ACH-001338	Neuroblastoma	CCLE	LAATPSSS	DEG_SCF_FBW7_1	0.6028
p.A41T	CHP-134	autonomic_ganglia	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	0.6028
p.L52V	ACH-002234	Head and Neck Cancer	CCLE	LAATPSSS	DEG_SCF_FBW7_1	0.1944
p.L52V	DOK	upper_aerodigestive_tract	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	0.1944
p.F35C	SCH	stomach	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	0.1944
p.A33T	SW1417	large_intestine	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAATPSSS

Degron related mutations and impact score

Drug responses associated with YY1AP1 mutations

All proteins holding degron of LAATPSSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H869	YY1-associated protein 1	DEG_SCF_FBW7_1	40:47	LAATPSSS	FBXW7	0.9941	More...