DegronMD

Uniprot ID: Q99742

Source protein: Neuronal PAS domain-containing protein 1

Source gene: NPAS1

Class: DEG_SCF_FBW7_2

Location: 223:230

E3 ligase: FBXW7

DEGRON score: 0.9728

ASA_SCORE: 89.3875

COIL: 0.7484

CONS_SCORE: 0.2853

DSS_SCORE: 0.5833

HELIX: 0.2035

FCONS_SCORE: 1.0171

RIG_SCORE: 0.6456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G219R	DO233205	GACA	ICGC	LADTPEIE	DEG_SCF_FBW7_2	0.6667
p.G219R	DO40978	UCEC	ICGC	LADTPEIE	DEG_SCF_FBW7_2	0.6667
p.G235S	DO233882	GACA	ICGC	LADTPEIE	DEG_SCF_FBW7_2	0.3056
p.S227I	DO229022	LICA	ICGC	LADTPEIE	DEG_SCF_FBW7_2	0.7341
p.G233C	DO229038	LICA	ICGC	LADTPEIE	DEG_SCF_FBW7_2	0.25
p.W225C	DO229008	LICA	ICGC	LADTPEIE	DEG_SCF_FBW7_2	0.7
p.W225C	DO37595	SKCM	ICGC	LADTPEIE	DEG_SCF_FBW7_2	0.7
p.G233R	DO46402	OV	ICGC	LADTPEIE	DEG_SCF_FBW7_2	0.25
p.S239Y	ACH-000831	Endometrial/Uterine Cancer	CCLE	LADTPEIE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99742	Neuronal PAS domain-containing protein 1	DEG_SCF_FBW7_2	223:230	LADTPEIE	FBXW7	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons