DegronMD - Q99742(NPAS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P203T	TCGA-A3-3320	KIRC	TCGA	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.P487Q	TCGA-BF-A1Q0	SKCM	TCGA	PATPRPE	DEG_SCF_FBW7_2	487:493	Mutation altering degron motif	0.7035
p.Q210E	DO51632	CESC	ICGC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.S217N	DO9860	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.818
p.G219R	DO233205	GACA	ICGC	LADTPEIE	DEG_SCF_FBW7_2	223:230	Mutation blocking phosphorylation signal	0.6667
p.G219R	DO233205	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation blocking phosphorylation signal	0.7222
p.G219R	DO40978	UCEC	ICGC	LADTPEIE	DEG_SCF_FBW7_2	223:230	Mutation blocking phosphorylation signal	0.6667
p.G219R	DO40978	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation blocking phosphorylation signal	0.7222
p.G235S	DO233882	GACA	ICGC	LADTPEIE	DEG_SCF_FBW7_2	223:230	Mutation substituting flanking lysine	0.3056
p.S227I	DO229022	LICA	ICGC	LADTPEIE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.7341
p.W204C	DO229027	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0833
p.G233C	DO229038	LICA	ICGC	LADTPEIE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.25
p.A213S	DO229045	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.7588
p.W225C	DO229008	LICA	ICGC	LADTPEIE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.7
p.W225C	DO37595	SKCM	ICGC	LADTPEIE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.7
p.G233R	DO46402	OV	ICGC	LADTPEIE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.25
p.S207F	DO50291	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1667
p.A212T	DO41807	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.R212C	DO41847	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.P208Q	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1944
p.P208Q	ACH-000983	Leukemia	CCLE	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1944
p.P208Q	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1944
p.P207L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1667
p.P207L	ACH-000983	Leukemia	CCLE	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1667
p.P207L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1667
p.R499W	SIDM01629	Melanoma	GDSC	PATPRPE	DEG_SCF_FBW7_2	487:493	Mutation rewiring degron network	0.1667
p.R499W	ACH-000404	Skin Cancer	CCLE	PATPRPE	DEG_SCF_FBW7_2	487:493	Mutation rewiring degron network	0.1667
p.I498T	ACH-000404	Skin Cancer	CCLE	PATPRPE	DEG_SCF_FBW7_2	487:493	Mutation rewiring degron network	0.1944
p.S212F	ACH-000477	Skin Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.S239Y	ACH-000831	Endometrial/Uterine Cancer	CCLE	LADTPEIE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.0833
p.E493K	ACH-002256	Leukemia	CCLE	PATPRPE	DEG_SCF_FBW7_2	487:493	Mutation altering degron motif	0.7022
p.E493K	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PATPRPE	DEG_SCF_FBW7_2	487:493	Mutation altering degron motif	0.7022

Kaplan plot for NPAS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NPAS1

UniProt ID: Q99742

Entrez ID: 4861

Protein name: Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NPAS1 in