DegronMD

Uniprot ID: Q99742

Source protein: Neuronal PAS domain-containing protein 1

Source gene: NPAS1

Class: DEG_SCF_FBW7_2

Location: 487:493

E3 ligase: FBXW7

DEGRON score: 0.8156

ASA_SCORE: 90.3286

COIL: 0.9283

CONS_SCORE: 0.3531

DSS_SCORE: 0.735

HELIX: 0.0267

FCONS_SCORE: 0.9934

RIG_SCORE: 0.6095

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P487Q	TCGA-BF-A1Q0	SKCM	TCGA	PATPRPE	DEG_SCF_FBW7_2	0.7035
p.R499W	SIDM01629	Melanoma	GDSC	PATPRPE	DEG_SCF_FBW7_2	0.1667
p.R499W	ACH-000404	Skin Cancer	CCLE	PATPRPE	DEG_SCF_FBW7_2	0.1667
p.I498T	ACH-000404	Skin Cancer	CCLE	PATPRPE	DEG_SCF_FBW7_2	0.1944
p.E493K	ACH-002256	Leukemia	CCLE	PATPRPE	DEG_SCF_FBW7_2	0.7022
p.E493K	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PATPRPE	DEG_SCF_FBW7_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99742	Neuronal PAS domain-containing protein 1	DEG_SCF_FBW7_2	487:493	PATPRPE	FBXW7	0.8156	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons