DegronMD

Uniprot ID: O75145

Source protein: Liprin-alpha-3

Source gene: PPFIA3

Class: DEG_SCF_FBW7_2

Location: 789:796

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 66.425

COIL: 0.8466

CONS_SCORE: 0.5009

DSS_SCORE: 0.7005

HELIX: 0.1051

FCONS_SCORE: 1.1255

RIG_SCORE: 0.5955

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D795Y	TCGA-2F-A9KP	BLCA	TCGA	LAGTPSDE	DEG_SCF_FBW7_2	0.6214
p.D795Y	DO51860	BLCA	ICGC	LAGTPSDE	DEG_SCF_FBW7_2	0.6214
p.E796K	TCGA-2F-A9KP	BLCA	TCGA	LAGTPSDE	DEG_SCF_FBW7_2	0.7022
p.E796K	DO51860	BLCA	ICGC	LAGTPSDE	DEG_SCF_FBW7_2	0.7022
p.M779T	TCGA-A5-A0G1	UCEC	TCGA	LAGTPSDE	DEG_SCF_FBW7_2	0.0556
p.M779T	DO42472	UCEC	ICGC	LAGTPSDE	DEG_SCF_FBW7_2	0.0556
p.L805P	TCGA-D8-A1XK	BRCA	TCGA	LAGTPSDE	DEG_SCF_FBW7_2	0.0833
p.L805P	DO4749	BRCA	ICGC	LAGTPSDE	DEG_SCF_FBW7_2	0.0833
p.A806S	DO228976	LICA	ICGC	LAGTPSDE	DEG_SCF_FBW7_2	0.0556
p.A806S	DO229019	LICA	ICGC	LAGTPSDE	DEG_SCF_FBW7_2	0.0556
p.A799D	SIDM01451	Pancreatic Carcinoma	GDSC	LAGTPSDE	DEG_SCF_FBW7_2	0.25
p.A799D	ACH-000933	Pancreatic Cancer	CCLE	LAGTPSDE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75145	Liprin-alpha-3	DEG_SCF_FBW7_2	789:796	LAGTPSDE	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons