DegronMD - O75145(PPFIA3)

FUNCTION: May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}.

GO - Biological processes (BP): neurotransmitter secretion [GO:0007269]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synapse organization [GO:0050808]; synaptic vesicle docking [GO:0016081]

GO - Molecular function (MF):

GO - Cellular component (CC): acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; epididymosome [GO:0098875]; glutamatergic synapse [GO:0098978]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T718N	TCGA-AX-A2HD	UCEC	TCGA	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation altering degron motif	0.8166
p.T718N	DO42608	UCEC	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation altering degron motif	0.8166
p.P711Q	TCGA-EE-A2ME	SKCM	TCGA	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation altering degron motif	0.7035
p.P711Q	DO38011	SKCM	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation altering degron motif	0.7035
p.E796K	TCGA-2F-A9KP	BLCA	TCGA	LAGTPSDE	DEG_SCF_FBW7_2	789:796	Mutation altering degron motif	0.7022
p.E796K	DO51860	BLCA	ICGC	LAGTPSDE	DEG_SCF_FBW7_2	789:796	Mutation altering degron motif	0.7022
p.S721P	SIDM01609	Endometrial Carcinoma	GDSC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation blocking phosphorylation signal	0.6944
p.S721P	ACH-000972	Endometrial/Uterine Cancer	CCLE	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation blocking phosphorylation signal	0.6944
p.P717L	DO51117	PRAD	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation altering degron motif	0.6471
p.D795Y	TCGA-2F-A9KP	BLCA	TCGA	LAGTPSDE	DEG_SCF_FBW7_2	789:796	Mutation altering degron motif	0.6214
p.D795Y	DO51860	BLCA	ICGC	LAGTPSDE	DEG_SCF_FBW7_2	789:796	Mutation altering degron motif	0.6214
p.P717T	DO228479	BRCA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation altering degron motif	0.5919
p.P716S	DO233226	GACA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation altering degron motif	0.5641
p.P719A	DO228479	BRCA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.3056
p.A709V	TCGA-A6-2686	COAD	TCGA	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.2778
p.A709V	DO7828	COAD	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.2778
p.A709V	DO220885	MELA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.2778
p.A709T	TCGA-BR-7707	STAD	TCGA	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.2778
p.A709T	DO38487	STAD	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.2778
p.A709T	DO229264	THCA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 34 entries

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Kaplan plot for PPFIA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPFIA3

UniProt ID: O75145

Entrez ID: 8541

Protein name: Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPFIA3 in