DegronMD

Uniprot ID: O75145

Source protein: Liprin-alpha-3

Source gene: PPFIA3

Class: DEG_SCF_FBW7_1

Location: 711:718

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 83.8625

COIL: 0.9614

CONS_SCORE: 0.447

DSS_SCORE: 0.8603

HELIX: 0.0188

FCONS_SCORE: 1.0659

RIG_SCORE: 0.5527

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A709V	TCGA-A6-2686	COAD	TCGA	PGDTPPPT	DEG_SCF_FBW7_1	0.2778
p.A709V	DO7828	COAD	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.2778
p.A709V	DO220885	MELA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.2778
p.T718N	TCGA-AX-A2HD	UCEC	TCGA	PGDTPPPT	DEG_SCF_FBW7_1	0.8166
p.T718N	DO42608	UCEC	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.8166
p.A709T	TCGA-BR-7707	STAD	TCGA	PGDTPPPT	DEG_SCF_FBW7_1	0.2778
p.A709T	DO38487	STAD	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.2778
p.A709T	DO229264	THCA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.2778
p.P711Q	TCGA-EE-A2ME	SKCM	TCGA	PGDTPPPT	DEG_SCF_FBW7_1	0.7035
p.P711Q	DO38011	SKCM	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.7035
p.E725Q	TCGA-UY-A9PA	BLCA	TCGA	PGDTPPPT	DEG_SCF_FBW7_1	0.1389
p.E725Q	DO219040	BLCA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.1389
p.P717T	DO228479	BRCA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.5919
p.P719A	DO228479	BRCA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.3056
p.R720H	DO228696	EOPC	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.2778
p.P716S	DO233226	GACA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.5641
p.R723H	DO233909	GACA	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.1944
p.M727I	DO230990	LUSC	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.0833
p.M727I	DO224554	LUSC	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.0833
p.P717L	DO51117	PRAD	ICGC	PGDTPPPT	DEG_SCF_FBW7_1	0.6471
p.S721P	SIDM01609	Endometrial Carcinoma	GDSC	PGDTPPPT	DEG_SCF_FBW7_1	0.6944
p.S721P	ACH-000972	Endometrial/Uterine Cancer	CCLE	PGDTPPPT	DEG_SCF_FBW7_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75145	Liprin-alpha-3	DEG_SCF_FBW7_1	711:718	PGDTPPPT	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons