DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_ODPH_VHL_1

Location: 1832:1843

E3 ligase: VHL

DEGRON score: 0.9755

ASA_SCORE: 88.7

COIL: 0.8355

CONS_SCORE: 0.5579

DSS_SCORE: 0.5623

HELIX: 0.151

FCONS_SCORE: 1.1381

RIG_SCORE: 0.7097

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1852A	DO44042	BLCA	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.0833
p.A1835V	DO8151	COAD	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.5825
p.L1841P	DO229010	COCA	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.7582
p.L1841P	DO229016	COCA	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.7582
p.L1841P	DO229003	COCA	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.7582
p.L1841P	DO229005	COCA	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.7582
p.L1841P	DO52365	LUSC	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.7582
p.P1846L	DO234305	ESAD	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.25
p.P1846L	DO51761	STAD	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.25
p.P1846L	ACH-002222	Leukemia	CCLE	LAPADEDELLPL	DEG_ODPH_VHL_1	0.25
p.P1846L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.25
p.P1828H	DO229022	LICA	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.2222
p.P1846S	DO232832	NACA	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.25
p.S1850F	DO51282	SKCM	ICGC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.1389
p.G1851R	ACH-000995	Leukemia	CCLE	LAPADEDELLPL	DEG_ODPH_VHL_1	0.1111
p.G1851R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.1111
p.A1833T	LCLC-103H	lung	COSMIC	LAPADEDELLPL	DEG_ODPH_VHL_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_ODPH_VHL_1	1832:1843	LAPADEDELLPL	VHL	0.9755	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons