DegronMD

Uniprot ID: Q9UJW9

Source protein: SERTA domain-containing protein 3

Source gene: SERTAD3

Class: DEG_ODPH_VHL_1

Location: 71:84

E3 ligase: VHL

DEGRON score: 0.98

ASA_SCORE: 81.9643

COIL: 0.8781

CONS_SCORE: 0.9783

DSS_SCORE: 0.365

HELIX: 0.0761

FCONS_SCORE: 1.0162

RIG_SCORE: 0.7335

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P73A	TCGA-90-A4ED	LUSC	TCGA	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.7503
p.P73A	DO45482	LUSC	ICGC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.7503
p.E87D	TCGA-EE-A2M8	SKCM	TCGA	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.25
p.E87D	DO38075	SKCM	ICGC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.25
p.R70C	TCGA-IH-A3EA	SKCM	TCGA	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.3056
p.R70C	DO37667	SKCM	ICGC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.3056
p.L71Q	TCGA-LG-A6GG	LIHC	TCGA	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.7765
p.L71Q	DO49699	LIHC	ICGC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.7765
p.P81L	TCGA-OD-A75X	SKCM	TCGA	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.6471
p.P81L	DO48601	SKCM	ICGC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.6471
p.L69I	DO228974	LICA	ICGC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.2778
p.S90C	SIDM00557	Neuroblastoma	GDSC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.1667
p.S90C	ACH-000345	Neuroblastoma	CCLE	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.1667
p.S90C	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.1667
p.A72T	SIDM01146	Gastric Carcinoma	GDSC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.7139
p.A72T	ACH-000932	Gastric Cancer	CCLE	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.7139
p.A72T	NCI-SNU-1	stomach	COSMIC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.7139
p.A74T	SIDM00220	Ovarian Carcinoma	GDSC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.6028
p.A74T	ACH-000962	Ovarian Cancer	CCLE	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.6028
p.A74T	OC-314	ovary	COSMIC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.6028
p.T61P	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPAPALPPEPLFL	DEG_ODPH_VHL_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJW9	SERTA domain-containing protein 3	DEG_ODPH_VHL_1	71:84	LAPAPALPPEPLFL	VHL	0.98	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons