DegronMD

Uniprot ID: Q6V0I7

Source protein: Protocadherin Fat 4

Source gene: FAT4

Class: DEG_ODPH_VHL_1

Location: 3:16

E3 ligase: VHL

DEGRON score: 0.7502

ASA_SCORE: 78.45

COIL: 0.8087

CONS_SCORE: 0.2991

DSS_SCORE: 0.3297

HELIX: 0.0546

FCONS_SCORE: 1.0412

RIG_SCORE: 0.7603

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L3V	TCGA-AA-3949	COAD	TCGA	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.6765
p.L3V	TCGA-BR-6453	STAD	TCGA	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.6765
p.L3V	TCGA-DM-A28F	COAD	TCGA	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.6765
p.L3V	DO7798	COAD	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.6765
p.L3V	DO9828	COAD	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.6765
p.L3V	DO227995	COCA	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.6765
p.L3V	DO234463	ESAD	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.6765
p.L3V	DO38543	STAD	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.6765
p.T4P	DO223732	CESC	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.8142
p.L24F	DO234218	ESAD	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.1111
p.R11L	DO233707	GACA	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.7316
p.A18S	DO228971	LICA	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.2778
p.T4M	DO27791	MALY	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.8534
p.P15S	DO220902	MELA	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.5641
p.P5T	DO27901	ORCA	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.7031
p.H17R	DO46518	OV	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.3056
p.A19G	DO28102	OV	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.25
p.V2I	DO37418	SKCM	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.3056
p.V5I	DO37406	SKCM	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.7076
p.F22V	DO41331	UCEC	ICGC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.1667
p.A4T	SIDM00506	Small Cell Lung Carcinoma	GDSC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.7139
p.A4T	ACH-000508	Lung Cancer	CCLE	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.7139
p.A4T	COR-L88	lung	COSMIC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.7139
p.R26Q	SIDM00118	Colorectal Carcinoma	GDSC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.0556
p.R26Q	ACH-001081	Colon/Colorectal Cancer	CCLE	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.0556
p.R26Q	HCC2998	large_intestine	COSMIC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.0556
p.L19I	SIDM01588	Endometrial Carcinoma	GDSC	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.25
p.L19I	ACH-000993	Endometrial/Uterine Cancer	CCLE	LAPDRATGRPWLPL	DEG_ODPH_VHL_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPDRATGRPWLPL

Degron related mutations and impact score

Drug responses associated with FAT4 mutations

All proteins holding degron of LAPDRATGRPWLPL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V0I7	Protocadherin Fat 4	DEG_ODPH_VHL_1	3:16	LAPDRATGRPWLPL	VHL	0.7502	More...