DegronMD

Uniprot ID: Q9BWH6

Source protein: RNA polymerase II-associated protein 1

Source gene: RPAP1

Class: DEG_ODPH_VHL_1

Location: 366:378

E3 ligase: VHL

DEGRON score: 0.7826

ASA_SCORE: 71.3385

COIL: 0.8059

CONS_SCORE: 0.4984

DSS_SCORE: 0.4594

HELIX: 0.1079

FCONS_SCORE: 0.7692

RIG_SCORE: 0.688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R358L	TCGA-22-4613	LUSC	TCGA	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.1111
p.R358L	DO26468	LUSC	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.1111
p.E383D	TCGA-2W-A8YY	CESC	TCGA	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.1944
p.E383D	DO223732	CESC	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.1944
p.E383Q	TCGA-ER-A19P	SKCM	TCGA	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.1944
p.E383Q	DO47623	SKCM	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.1944
p.Q362H	TCGA-GN-A26C	SKCM	TCGA	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.2222
p.Q362H	DO37782	SKCM	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.2222
p.G363E	DO218167	BRCA	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.25
p.F359L	DO229022	LICA	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.1389
p.F359L	DO229031	LICA	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.1389
p.L365Q	DO232855	NACA	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWH6	RNA polymerase II-associated protein 1	DEG_ODPH_VHL_1	366:378	LAPDVDLPTHLGL	VHL	0.7826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons