DegronMD - Q9BWH6(RPAP1)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R358L	TCGA-22-4613	LUSC	TCGA	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.1111
p.R358L	DO26468	LUSC	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.1111
p.E383D	TCGA-2W-A8YY	CESC	TCGA	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.1944
p.E383D	DO223732	CESC	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.1944
p.P322S	TCGA-97-7554	LUAD	TCGA	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation altering degron motif	0.6752
p.P322S	DO23592	LUAD	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation altering degron motif	0.6752
p.A317S	TCGA-AX-A06F	UCEC	TCGA	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation rewiring degron network	0.3056
p.A317S	DO41752	UCEC	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation rewiring degron network	0.3056
p.E383Q	TCGA-ER-A19P	SKCM	TCGA	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.1944
p.E383Q	DO47623	SKCM	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.1944
p.Q362H	TCGA-GN-A26C	SKCM	TCGA	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.2222
p.Q362H	DO37782	SKCM	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.2222
p.A317E	TCGA-IN-A6RL	STAD	TCGA	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation rewiring degron network	0.3056
p.A317E	DO51738	STAD	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation rewiring degron network	0.3056
p.G363E	DO218167	BRCA	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.25
p.V320M	DO230334	COCA	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation altering degron motif	0.6097
p.V320M	DO230990	LUSC	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation altering degron motif	0.6097
p.L327M	DO228948	LICA	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation rewiring degron network	0.2778
p.F359L	DO229022	LICA	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.1389
p.F359L	DO229031	LICA	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.1389
p.D330G	DO232858	NACA	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation rewiring degron network	0.1944
p.L365Q	DO232855	NACA	ICGC	LAPDVDLPTHLGL	DEG_ODPH_VHL_1	366:378	Mutation rewiring degron network	0.3056
p.E310K	SIDM00024	Non-Cancerous	GDSC	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation rewiring degron network	0.1111
p.E310K	SIDM00164	Biliary Tract Carcinoma	GDSC	LPVTPQKE	DEG_SCF_FBW7_2	318:325	Mutation rewiring degron network	0.1111

Kaplan plot for RPAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPAP1

UniProt ID: Q9BWH6

Entrez ID: 26015

Protein name: RNA polymerase II-associated protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPAP1 in