DegronMD

Uniprot ID: Q9BWH6

Source protein: RNA polymerase II-associated protein 1

Source gene: RPAP1

Class: DEG_SCF_FBW7_2

Location: 318:325

E3 ligase: FBXW7

DEGRON score: 0.5991

ASA_SCORE: 84.45

COIL: 0.7435

CONS_SCORE: 0.3319

DSS_SCORE: 0.4358

HELIX: 0.191

FCONS_SCORE: 0.9345

RIG_SCORE: 0.7385

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P322S	TCGA-97-7554	LUAD	TCGA	LPVTPQKE	DEG_SCF_FBW7_2	0.6752
p.P322S	DO23592	LUAD	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	0.6752
p.A317S	TCGA-AX-A06F	UCEC	TCGA	LPVTPQKE	DEG_SCF_FBW7_2	0.3056
p.A317S	DO41752	UCEC	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	0.3056
p.A317E	TCGA-IN-A6RL	STAD	TCGA	LPVTPQKE	DEG_SCF_FBW7_2	0.3056
p.A317E	DO51738	STAD	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	0.3056
p.V320M	DO230334	COCA	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	0.6097
p.V320M	DO230990	LUSC	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	0.6097
p.L327M	DO228948	LICA	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	0.2778
p.D330G	DO232858	NACA	ICGC	LPVTPQKE	DEG_SCF_FBW7_2	0.1944
p.E310K	SIDM00024	Non-Cancerous	GDSC	LPVTPQKE	DEG_SCF_FBW7_2	0.1111
p.E310K	SIDM00164	Biliary Tract Carcinoma	GDSC	LPVTPQKE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWH6	RNA polymerase II-associated protein 1	DEG_SCF_FBW7_2	318:325	LPVTPQKE	FBXW7	0.5991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons