DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPFPD
Uniprot ID:
Q6UX68
Source protein:
XK-related protein 5
Source gene:
XKR5
Class:
LIG_APCC_ABBA_1
Location:
588:593
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8837
ASA_SCORE:
73.1333
COIL:
0.8577
CONS_SCORE:
0.2802
DSS_SCORE:
0.5341
HELIX:
0.0672
FCONS_SCORE:
0.8931
RIG_SCORE:
0.6947
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with XKR5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPFPD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6UX68
XK-related protein 5
LIG_APCC_ABBA_1
588:593
LAPFPD
APC,CDC20,FZR1
0.8837
More...