DegronMD

Uniprot ID: P48426

Source protein: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

Source gene: PIP4K2A

Class: DEG_ODPH_VHL_1

Location: 327:338

E3 ligase: VHL

DEGRON score: 0.8782

ASA_SCORE: 54.85

COIL: 0.7909

CONS_SCORE: 0.3652

DSS_SCORE: 0.4781

HELIX: 0.0962

FCONS_SCORE: 1.0436

RIG_SCORE: 0.7044

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K342N	TCGA-22-4613	LUSC	TCGA	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.3333
p.K342N	DO26468	LUSC	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.3333
p.D337N	TCGA-D1-A16X	UCEC	TCGA	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.5821
p.D337N	DO41799	UCEC	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.5821
p.T347K	DO229029	LICA	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.0833
p.T328N	DO229045	LICA	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.7055
p.V318I	DO220875	MELA	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.0833
p.I342N	DO30490	OV	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.3333
p.F341L	DO41488	UCEC	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.25
p.V338I	SIDM01943	Colorectal Carcinoma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.5965
p.P325S	SIDM00190	Melanoma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.2778
p.P325S	ACH-002097	Skin Cancer	CCLE	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.2778
p.P325S	CP66-MEL	skin	COSMIC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.2778
p.S323R	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.2222
p.S323R	ACH-000496	Lung Cancer	CCLE	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.2222
p.S323R	NCI-H1792	lung	COSMIC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.2222
p.G330R	SIDM01134	Small Cell Lung Carcinoma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.6457
p.G330R	ACH-000292	Lung Cancer	CCLE	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.6457
p.G330R	NCI-H841	lung	COSMIC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.6457
p.L327M	SIDM00309	Mesothelioma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.711
p.L327M	SIDM00793	Burkitt's Lymphoma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.711
p.A324T	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.25
p.N346T	SK-MEL-1	skin	COSMIC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48426	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	DEG_ODPH_VHL_1	327:338	LAPGEFDPNIDV	VHL	0.8782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPGEFDPNIDV

Degron related mutations and impact score

Drug responses associated with PIP4K2A mutations

All proteins holding degron of LAPGEFDPNIDV