DegronMD - P48426(PIP4K2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K342N	TCGA-22-4613	LUSC	TCGA	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation substituting flanking lysine	0.3333
p.K342N	DO26468	LUSC	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation substituting flanking lysine	0.3333
p.D315H	TCGA-86-A4JF	LUAD	TCGA	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.6577
p.D337N	TCGA-D1-A16X	UCEC	TCGA	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation altering degron motif	0.5821
p.D337N	DO41799	UCEC	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation altering degron motif	0.5821
p.P313L	TCGA-EE-A29D	SKCM	TCGA	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7582
p.H308Y	TCGA-ER-A19S	SKCM	TCGA	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.3056
p.E303K	TCGA-XF-A9SP	BLCA	TCGA	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1667
p.A314D	DO229019	LICA	ICGC	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7793
p.T347K	DO229029	LICA	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.0833
p.T328N	DO229045	LICA	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation altering degron motif	0.7055
p.V318I	DO220875	MELA	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.0833
p.V318I	DO220875	MELA	ICGC	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2778
p.I342N	DO30490	OV	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation substituting flanking lysine	0.3333
p.T303N	DO43186	UCEC	ICGC	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1667
p.F341L	DO41488	UCEC	ICGC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.25
p.V338I	SIDM01943	Colorectal Carcinoma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation altering degron motif	0.5965
p.P325S	SIDM00190	Melanoma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.2778
p.P325S	SIDM00190	Melanoma	GDSC	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.0833
p.P325S	ACH-002097	Skin Cancer	CCLE	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.2778
p.P325S	ACH-002097	Skin Cancer	CCLE	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.0833
p.P325S	CP66-MEL	skin	COSMIC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.2778
p.P325S	CP66-MEL	skin	COSMIC	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.0833
p.S323R	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.2222
p.S323R	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1389
p.S323R	ACH-000496	Lung Cancer	CCLE	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.2222
p.S323R	ACH-000496	Lung Cancer	CCLE	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1389
p.S323R	NCI-H1792	lung	COSMIC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.2222
p.S323R	NCI-H1792	lung	COSMIC	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1389
p.T307S	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2778
p.T307S	ACH-000953	Leukemia	CCLE	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2778
p.T307S	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2778
p.G330R	SIDM01134	Small Cell Lung Carcinoma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation altering degron motif	0.6457
p.G330R	ACH-000292	Lung Cancer	CCLE	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation altering degron motif	0.6457
p.G330R	NCI-H841	lung	COSMIC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation altering degron motif	0.6457
p.L327M	SIDM00309	Mesothelioma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation altering degron motif	0.711
p.L327M	SIDM00793	Burkitt's Lymphoma	GDSC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation altering degron motif	0.711
p.A324T	REH	haematopoietic and lymphoid tissue	COSMIC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.25
p.A324T	REH	haematopoietic and lymphoid tissue	COSMIC	PVGTPPDS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1111
p.N346T	SK-MEL-1	skin	COSMIC	LAPGEFDPNIDV	DEG_ODPH_VHL_1	327:338	Mutation rewiring degron network	0.1111

Kaplan plot for PIP4K2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIP4K2A

UniProt ID: P48426

Entrez ID: 5305

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIP4K2A in