DegronMD

Uniprot ID: P48426

Source protein: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

Source gene: PIP4K2A

Class: DEG_SCF_FBW7_1

Location: 309:316

E3 ligase: FBXW7

DEGRON score: 0.9546

ASA_SCORE: 71.325

COIL: 0.9465

CONS_SCORE: 0.3314

DSS_SCORE: 0.8757

HELIX: 0.0198

FCONS_SCORE: 0.9078

RIG_SCORE: 0.5218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D315H	TCGA-86-A4JF	LUAD	TCGA	PVGTPPDS	DEG_SCF_FBW7_1	0.6577
p.P313L	TCGA-EE-A29D	SKCM	TCGA	PVGTPPDS	DEG_SCF_FBW7_1	0.7582
p.H308Y	TCGA-ER-A19S	SKCM	TCGA	PVGTPPDS	DEG_SCF_FBW7_1	0.3056
p.E303K	TCGA-XF-A9SP	BLCA	TCGA	PVGTPPDS	DEG_SCF_FBW7_1	0.1667
p.A314D	DO229019	LICA	ICGC	PVGTPPDS	DEG_SCF_FBW7_1	0.7793
p.V318I	DO220875	MELA	ICGC	PVGTPPDS	DEG_SCF_FBW7_1	0.2778
p.T303N	DO43186	UCEC	ICGC	PVGTPPDS	DEG_SCF_FBW7_1	0.1667
p.P325S	SIDM00190	Melanoma	GDSC	PVGTPPDS	DEG_SCF_FBW7_1	0.0833
p.P325S	ACH-002097	Skin Cancer	CCLE	PVGTPPDS	DEG_SCF_FBW7_1	0.0833
p.P325S	CP66-MEL	skin	COSMIC	PVGTPPDS	DEG_SCF_FBW7_1	0.0833
p.S323R	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	PVGTPPDS	DEG_SCF_FBW7_1	0.1389
p.S323R	ACH-000496	Lung Cancer	CCLE	PVGTPPDS	DEG_SCF_FBW7_1	0.1389
p.S323R	NCI-H1792	lung	COSMIC	PVGTPPDS	DEG_SCF_FBW7_1	0.1389
p.T307S	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PVGTPPDS	DEG_SCF_FBW7_1	0.2778
p.T307S	ACH-000953	Leukemia	CCLE	PVGTPPDS	DEG_SCF_FBW7_1	0.2778
p.T307S	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PVGTPPDS	DEG_SCF_FBW7_1	0.2778
p.A324T	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PVGTPPDS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48426	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	DEG_SCF_FBW7_1	309:316	PVGTPPDS	FBXW7	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons