DegronMD

Uniprot ID: Q6X4W1

Source protein: NMDA receptor synaptonuclear signaling and neuronal migration factor

Source gene: NSMF

Class: DEG_ODPH_VHL_1

Location: 173:184

E3 ligase: VHL

DEGRON score: 0.9109

ASA_SCORE: 83.1417

COIL: 0.9047

CONS_SCORE: 0.442

DSS_SCORE: 0.6061

HELIX: 0.0621

FCONS_SCORE: 1.0515

RIG_SCORE: 0.6365

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A174V	TCGA-22-4599	LUSC	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.6936
p.A174V	DO26945	LUSC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.6936
p.P177T	TCGA-56-8626	LUSC	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.5919
p.P177T	DO45506	LUSC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.5919
p.P179H	TCGA-AP-A059	UCEC	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.6583
p.P179H	DO41361	UCEC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.6583
p.R180W	TCGA-AP-A1DV	UCEC	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.7523
p.R180W	DO43186	UCEC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.7523
p.R180G	TCGA-FD-A6TC	BLCA	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.6457
p.R180G	DO49755	BLCA	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.6457
p.N193H	DO223831	KIRC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.0833
p.A179T	DO219357	PRAD	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.7139
p.R163C	DO48665	SKCM	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.0556
p.E182K	DO38495	STAD	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.7022
p.E182K	DO43907	UCEC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.7022
p.P171T	DO223282	UCEC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6X4W1	NMDA receptor synaptonuclear signaling and neuronal migration factor	DEG_ODPH_VHL_1	173:184	LAPGPTPRAFGL	VHL	0.9109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons