DegronMD

Uniprot ID: Q5JPI3

Source protein: Uncharacterized protein C3orf38

Source gene: C3orf38

Class: DEG_ODPH_VHL_1

Location: 281:293

E3 ligase: VHL

DEGRON score: 0.8682

ASA_SCORE: 79.3385

COIL: 0.8303

CONS_SCORE: 0.3181

DSS_SCORE: 0.289

HELIX: 0.0233

FCONS_SCORE: 0.7659

RIG_SCORE: 0.7348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V291A	TCGA-06-5416	GBM	TCGA	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.6936
p.V291A	DO10880	GBM	ICGC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.6936
p.E294V	TCGA-55-A492	LUAD	TCGA	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.3056
p.E294V	DO44726	LICA	ICGC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.3056
p.E294V	DO23708	LUAD	ICGC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.3056
p.P289S	TCGA-D9-A6EC	SKCM	TCGA	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.5641
p.P289S	DO50291	SKCM	ICGC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.5641
p.P289S	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.5641
p.P289S	SIDM00202	Ewing's Sarcoma	GDSC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.5641
p.P289S	SIDM00327	Hodgkin's Lymphoma	GDSC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.5641
p.P289L	TCGA-D9-A6EC	SKCM	TCGA	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.6471
p.P289L	DO50291	SKCM	ICGC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.6471
p.L281I	TCGA-EE-A2GT	SKCM	TCGA	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.6063
p.L281I	DO37946	SKCM	ICGC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.6063
p.S280F	TCGA-FS-A4F0	SKCM	TCGA	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.3056
p.S280F	DO37891	SKCM	ICGC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.3056
p.P289A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.6392
p.P289A	ACH-000937	Leukemia	CCLE	LAPGTLPKPSVKF	DEG_ODPH_VHL_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JPI3	Uncharacterized protein C3orf38	DEG_ODPH_VHL_1	281:293	LAPGTLPKPSVKF	VHL	0.8682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons