DegronMD

Uniprot ID: Q6ZRC1

Source protein: Uncharacterized protein C4orf50

Source gene: C4orf50

Class: DEG_ODPH_VHL_1

Location: 130:143

E3 ligase: VHL

DEGRON score: 0.9214

ASA_SCORE: 73.6929

COIL: 0.7887

CONS_SCORE: 0.7595

DSS_SCORE: 0.3297

HELIX: 0.1556

FCONS_SCORE: 1.0366

RIG_SCORE: 0.7258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N149K	DO52708	CLLE	ICGC	LAPGVPETSHHLDV	DEG_ODPH_VHL_1	0.1667
p.G123R	DO50970	LICA	ICGC	LAPGVPETSHHLDV	DEG_ODPH_VHL_1	0.1389
p.S147N	DO50970	LICA	ICGC	LAPGVPETSHHLDV	DEG_ODPH_VHL_1	0.2222
p.S131N	DO232761	PBCA	ICGC	LAPGVPETSHHLDV	DEG_ODPH_VHL_1	0.7069
p.N136S	DO218848	SKCA	ICGC	LAPGVPETSHHLDV	DEG_ODPH_VHL_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRC1	Uncharacterized protein C4orf50	DEG_ODPH_VHL_1	130:143	LAPGVPETSHHLDV	VHL	0.9214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons