DegronMD

Uniprot ID: Q6ZMM2

Source protein: ADAMTS-like protein 5

Source gene: ADAMTSL5

Class: LIG_APCC_ABBA_1

Location: 430:435

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8112

ASA_SCORE: 77.8667

COIL: 0.7902

CONS_SCORE: 0.5976

DSS_SCORE: 0.1394

HELIX: 0.0255

FCONS_SCORE: 1.0605

RIG_SCORE: 0.7939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L433V	TCGA-56-7222	LUSC	TCGA	LAPHRD	LIG_APCC_ABBA_1	0.6765
p.P422S	TCGA-CK-4951	COAD	TCGA	LAPHRD	LIG_APCC_ABBA_1	0.1111
p.H424R	DO51920	BLCA	ICGC	LAPHRD	LIG_APCC_ABBA_1	0.1667
p.P432S	DO10582	COAD	ICGC	LAPHRD	LIG_APCC_ABBA_1	0.6752
p.P428L	DO233767	GACA	ICGC	LAPHRD	LIG_APCC_ABBA_1	0.2778
p.P426T	DO229022	LICA	ICGC	LAPHRD	LIG_APCC_ABBA_1	0.2222
p.D435E	DO229045	LICA	ICGC	LAPHRD	LIG_APCC_ABBA_1	0.5647
p.L443V	DO26842	LUSC	ICGC	LAPHRD	LIG_APCC_ABBA_1	0.1111
p.H424Y	DO229216	THCA	ICGC	LAPHRD	LIG_APCC_ABBA_1	0.1667
p.R432C	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	LAPHRD	LIG_APCC_ABBA_1	0.8301
p.R432C	ACH-000605	Esophageal Cancer	CCLE	LAPHRD	LIG_APCC_ABBA_1	0.8301
p.R432C	TE-6	oesophagus	COSMIC	LAPHRD	LIG_APCC_ABBA_1	0.8301
p.L444P	SIDM00333	Endometrial Carcinoma	GDSC	LAPHRD	LIG_APCC_ABBA_1	0.0833
p.L444P	ACH-000988	Endometrial/Uterine Cancer	CCLE	LAPHRD	LIG_APCC_ABBA_1	0.0833
p.L444P	MFE-319	endometrium	COSMIC	LAPHRD	LIG_APCC_ABBA_1	0.0833
p.R432H	SIDM00837	Colorectal Carcinoma	GDSC	LAPHRD	LIG_APCC_ABBA_1	0.8244
p.R432H	SIDM01641	Non-Cancerous	GDSC	LAPHRD	LIG_APCC_ABBA_1	0.8244
p.R432H	SIDM01012	Other Blood Cancers	GDSC	LAPHRD	LIG_APCC_ABBA_1	0.8244
p.R432H	SIDM01724	Melanoma	GDSC	LAPHRD	LIG_APCC_ABBA_1	0.8244
p.D425V	SIDM01608	Endometrial Carcinoma	GDSC	LAPHRD	LIG_APCC_ABBA_1	0.1944
p.D425V	ACH-000990	Endometrial/Uterine Cancer	CCLE	LAPHRD	LIG_APCC_ABBA_1	0.1944
p.R434W	ACH-000971	Colon/Colorectal Cancer	CCLE	LAPHRD	LIG_APCC_ABBA_1	0.7523

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMM2	ADAMTS-like protein 5	LIG_APCC_ABBA_1	430:435	LAPHRD	APC,CDC20,FZR1	0.8112	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons